Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 1861-1876 z 1876
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Future changes in snowpack will impact seasonal runoff and low flows in Czechia
původní článek
open access
vydavatelská verze
2021
,Journal of Hydrology: Regional Studies [online]
,37
(October)
Study Region Central Europe, Czechia. Study Focus Mountains are referred to as "water towers" because they substantially affect the hydrology of downstream areas. However, snow storages will decrease in the future due to ...
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Electrophysiological and computational analysis of Ca(v)3.2 channel variants associated with familial trigeminal neuralgia
původní článek
embargo
vydavatelská verze
2022
,Molecular Brain
,15
(November)
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic ...
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Group of cancer immunotherapy and molecular epidemiology of virus infections
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The group is composed of the team of Laboratory of Molecular and Tumor Virology (headed by Ruth Tachezy) and Laboratory of Immunotherapy (headed by Michal Šmahel). While the research of the team led by Ruth Tachezy focuses ...
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Discovery of new antiviral defense mechanisms
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(3)
In this project, we will study mechanisms of hepatitis B virus escape from adaptive and innate immunity to discover novel antiviral therapeutic targets for the development of drugs to treat chronically infected patients
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Development of antimicrobial agents with activity against drug-resistant bacteria
abstrakt v časopisu
open access
vydavatelská verze
2022
,Czech Chemical Society Symposium Series
,20
(6)
Tuberculosis (TB) is a widespread infectious disease predominantly caused by Mycobacterium tuberculosis (M. tuberculosis). The discovery and widespread use of antimicrobials effective against TB starting in the middle of ...
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Phlebovirus Transmission by Sand Flies
abstrakt v konferenčním sborníku
open access
postprint
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Arboviruses of the genus Phlebovirusare currently represented by 67 species found in Eurasia, Africa, and the Americas1. Although they have a great impact on human and animal health, information about their biology ...
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Transcription apparatus of the yeast virus-like elements is closely related to the poxviral transcription apparatus
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
We employed virus-like elements (VLEs) pGKL1,2 from Kluyveromyces lactisas a model to investigate the previously neglected transcriptome of the broader group of yeast cytoplasmic linear dsDNA VLEs. We found that RNA ...
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Understanding the molecular mechanisms of viruses and host interactions
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Our research is focused on two objectives, first, the study of interactions between nuclear proteins and viral components which could result in the restriction or establishment of the infection, and second, the elucidation ...
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Role of PML nuclear bodies during mouse polyomavirus infection: PML protein isoforms and the non-canonical histone H3.3
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The possible restriction function of promyelocytic nuclear bodies (PML NBs) and their associated proteins in polyomavirus infection was studied. At first, We found that the absence of PML protein positively affects the ...
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Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
We previously described that Murine polyomavirus MPyV induces type I interferon (IFN) responses via the sensors, p204 (human IFI16 homolog) and cGAS which sense viral genomes and micronucleus-like bodies generated during ...
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Skin and oral virome in psoriasis patients on biologic therapy
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The viral communities represent the most abundant microbiota population in humans. Viruses, together with other microbiota such as bacteria and fungi, form a dynamic ecosystem that influences the health of the host. The ...
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Current research on A-to-I editing in the Laboratory of RNA biochemistry, Faculty of Science, Charles University
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The paper summarizes the current status and planned research in the field of RNA editing at the Laboratory of RNA Biochemistry, Faculty of Science, Charles University
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Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Human papillomaviruses induce a subset of head and neck squamous cell carcinomas and anogenital cancers, particularly cervical cancer. The main viral proteins that contribute to tumorigenesis are the E6 and E7 oncoproteins, ...
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Vitamin D3 Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals
původní článek
embargo
vydavatelská verze
2023
,Life
,13
(3)
Background: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800-2000 IU/day. The aim of our study was to determine ...
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Actin depolymerization is able to increase plant resistance against pathogens via activation of salicylic acid signalling pathway
původní článek
embargo
vydavatelská verze
2019
,Scientific Reports
,9
(1)
The integrity of the actin cytoskeleton is essential for plant immune signalling. Consequently, it is generally assumed that actin disruption reduces plant resistance to pathogen attack. Here, we demonstrate that actin ...
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Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators
původní článek
open access
vydavatelská verze
2022
,International Journal of Molecular Sciences
,23
(18)
Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated ...
