Repozitář publikační činnosti UK: Recent submissions
Now showing items 1-20 of 1828
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Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction - focus on large B-cell lymphomas and follicular lymphomas
summarizing article
open access
published version
2025
,Informa Plc
,Expert Review of Molecular Diagnostics
,25
(6)
INTRODUCTION: Pathogenesis of large B-cell lymphomas (LBCL) and follicular lymphomas (FL) is a multistep process associated with development of diverse DNA alterations and consequent deregulation of critical cellular ...
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Deficiency of miR-155 in leukemic B-cells results in cell cycle arrest and deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network
original article
open access
published version
2025
,Archives of Medical Research
,56
(3)
Background. Cell cycle progression and leukemia development are tightly regulated processes in which even a small imbalance in the expression of cell cycle regulatory molecules and microRNAs (miRNAs) can lead to an increased ...
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EVIDENCE BASED SELECTION OF HYPERPARAMETERS FOR EPITHELIAL SEGMENTATION IN WHOLE SLIDE IMMUNOHISTOCHEMISTRY IMAGES: FROM NORMAL MUCOSA TO COLORECTAL CANCER
original article
open access
submitted version
2026
Background. Accurate delineation of the epithelial compartment is a critical prerequisite for reproducible quantitative analysis in digital pathology, particularly in colorectal cancer (CRC) where malignant glands determine ...
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Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
original article
open access
published version
2026
,Springer
,Cancer Immunology, Immunotherapy
,75
(1)
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
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Exploring the full spectrum of reproductive experiences
original article
open access
published version
2026
,University of Bamberg Press
,Journal of Family Research
,38
(January 13, 2026)
Objective: The study examines changes across cohorts in terms of the timing and frequency of the full spectrum of reproductive events and explores whether these reproductive trajectories reflect broader trends towards the ...
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Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study
original article
open access
published version
2026
,Elsevier España
,Annals of Hepatology
,31
(1)
Introduction and Objectives: Bilirubin is negatively associated with neurodegenerative diseases, including multiple sclerosis (MS). Since previous studies were small or did not evaluate all diagnostic aspects, the objective ...
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Ruthenium-enhanced curcumin derivatives target tumor growth and cancer-related inflammation in head and neck cancer models
original article
open access
published version
2025
,Frontiers Media SA
,Frontiers in Oncology
,15
(December)
Introduction Head and neck cancers (HNC) remain a significant clinical challenge, particularly due to their association with chronic inflammation triggered by tobacco carcinogens and human papillomavirus (HPV) infection. ...
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Exploring the full spectrum of reproductive experiences
original article
open access
published version
2026
,University of Bamberg Press
,Journal of Family Research
,38
(January 13, 2026)
Objective: The study examines changes across cohorts in terms of the timing and frequency of the full spectrum of reproductive events and explores whether these reproductive trajectories reflect broader trends towards the ...
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Targeting tumors and inflammation: A quinoline–chalcone ruthenium complex with therapeutic promise
original article
open access
published version
2026
,Elsevier
,Biomedicine & Pharmacotherapy
,194
(January)
Head and neck cancers remain among the most challenging malignancies to treat and are often linked to lifestyle-related risk factors such as smoking and alcohol consumption. These factors not only initiate tumor development ...
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Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study
original article
open access
published version
2026
,Springer-Verlag France
,Hernia
,30
(1)
PURPOSE: Incisional hernia is a common postoperative complication following abdominal surgery. Despite the use of synthetic meshes, recurrence rates remain high. This study aimed to develop and evaluate a biodegradable, ...
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Parental decision-making regarding vaccination: the role of preschool enrolment sanctions, family policies and childcare expectation
original article
open access
published version
2025
,Taylor & Francis
,European Societies
,27
(5)
The Czech Republic exemplifies a country with a mandatory childhood vaccination system. A child who has not completed compulsory vaccinations cannot be admitted to preschool until age 5. This paper discusses this measure's ...
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Environmental stability of untreated neutral metalliferous mine drainage sludge after 100 years of weathering
original article
open access
published version
2025
,Kluwer
,Environmental Geochemistry and Health
,47
(12)
Untreated neutral metalliferous mine drainage sludge deposited without environmental protection for over a century was studied to assess its long-term stability. The lack of long-term stability data on such untreated sludge ...
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Silver is immobile in Ag-rich mine waste: Isotopic evidence from anthropogenic soils
original article
open access
published version
2026
,Elsevier
,Journal of Geochemical Exploration
,282
(March)
This study presents silver (Ag) stable isotope ratios (expressed as delta Ag-109) combined with mineralogy and speciation data in Ag-contaminated anthropogenic soils from a historic mining area at Kutna Hora, Czech Republic. ...
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Mutational landscape of lung adenocarcinoma in Czechia
original article
open access
published version
2026
,Elsevier Inc.
,Cancer Treatment and Research Communications
,46
Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...
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Dopady pandemie covidu-19 na vnímání rizika a naplňování péče v rámci různých „světů“ zaměstnanců domova pro seniory
Exploring the Effects of the Covid-19 Pandemic on Risk Perception and Care Dynamics Among Staff in Residential Homes for Older Adults
original article
open access
published version
2025
,Sociologický ústav AV ČR v.v.i.
,Sociologický časopis / Czech Sociological Review
Tato studie si klade za cíl rozšířit porozumění dopadu pandemie Covid-19 a souvisejících opatření na fungování zařízení dlouhodobé péče pro starší osoby a na zaměstnance pracující v těchto institucích. Článek prezentuje ...
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Vector competence of sand flies to Leishmania parasites and Toscana virus
abstract in conference proceedings
open access
accepted version
2025
,9th Society for Vector Ecology (SOVE) International Congress: Connecting Vector Science Globally - Abstract Book
Phlebotomine sand flies transmit a range of human pathogens, including Leishmania parasites and viruses such as Toscana virus (TOSV). Recent studies have shown that Phlebotomus tobbi and P. sergenti, two species widespread ...
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Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth
original article
open access
published version
2025
,Springer Nature
,Scientific Reports
,15
(1)
Nucleos(t)ides are essential for DNA/RNA synthesis, energy metabolism, and signaling, yet their roles in placental development remain poorly understood. The placenta undergoes dynamic metabolic adaptations throughout ...
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Mezi bolestí a nedůvěrou: Sociální kontext sporných onemocnění na příkladu fibromyalgie
Between Pain and Distrust: The Social Context of Contested Illnesses Viewed through the Case of Fibromyalgia
original article
open access
published version
2025
,Sociologický ústav SAV
,Sociológia
,57
(5)
This study explores the illness narratives of individuals diagnosed with fibromyalgia, focusing on how the condition's invisibility and the challenges surrounding the diagnostic process shape patients' everyday experiences ...
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Protestantské konfesijní školy v českých zemích z kvantitativního hlediska
A Quantitative Analysis of Protestant Confessional Schools in the Czech Lands
original article
open access
published version
2025
,Národní pedagogické muzeum a knihovna J. A. Komenského
,Historia scholastica
,11
(2)
Autor analyzuje konfesionální protestantské školy v českých zemích, zakládané v "dlouhém" 19. století a v některých případech trvající do století 20., z kvantitativního hlediska: kde, kdy a proč byly tyto školy zřizovány, ...
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Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure-Activity Relationship
original article
open access
published version
2025
,Blackwell
,Influenza and Other Respiratory Viruses
,19
(10)
Background: Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against ...
