Repozitář publikační činnosti UK: Recent submissions
Now showing items 1701-1720 of 2164
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TET protein inhibitors: Potential and limitations
summarizing article
open access
published version
2023
,Biomedicine & Pharmacotherapy
,166
(October)
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. ...
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Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
original article
open access
published version
2023
,eLife
,12
(July)
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically ...
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Double perovskite Cs2AgBiBr6 radiation sensor: synthesis and characterization of single crystals
original article
open access
published version
2022
,Journal of Materials Science [online]
,57
(4)
Single crystals of lead-free halide double perovskite Cs(2)AgBiBr(6) sensor material manifest a remarkable potential for application in radiation detection and imaging. In this study, the purity and crystallinity of ...
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HBV-induced microenvironment reduces pDC response to TLR7/9 stimulation
abstract in e-form
open access
published version
2023
Hepatitis B virus (HBV) is an infectious agent that causes acute hepatitis, but can also lead to chronic inflammation, and, consequently, to hepatocellular carcinoma. HBV is described as "stealth virus", since it avoids ...
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Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery
original article
open access
published version
2023
,Diagnostics
,13
(20)
In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was ...
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Carl Schmitt and Democratic Backsliding
original article
embargoed access
updated version
2023
,Contemporary Political Theory
,22
(3)
This Critical Exchange suggests that Schmittian inspirations abound in countries that experience democratic backsliding. Sometimes, Schmitt's ideas are used explicitly, but more often they are implicit in the actions of ...
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Carl Schmitt and Democratic Backsliding
original article
embargoed access
published version
2023
,Contemporary Political Theory
,22
(3)
This Critical Exchange suggests that Schmittian inspirations abound in countries that experience democratic backsliding. Sometimes, Schmitt's ideas are used explicitly, but more often they are implicit in the actions of ...
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Acute Effects of Isometric Conditioning Activity on the Viscoelastic Properties of Muscles and Sprint and Jumping Performance in Handball Players
original article
restricted access
published version
2023
,Journal of Strength and Conditioning Research
,37
(7)
Krzysztofik, M, Spieszny, M, Trybulski, R, Wilk, M, Pisz, A, Kolinger, D, Filip-Stachnik, A, and Stastny, P. Acute effects of isometric conditioning activity on the viscoelastic properties of muscles and sprint and jumping ...
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Sleep quality and sleep routines as mediators of stressors and life satisfaction in Czech university students: a structural equation model
original article
embargoed access
published version
2023
,Frontiers in Psychology
,2023
(14)
Introduction: Sleep is especially important to overall well-being. Some aspects of sleep have been well documented, for example sleep quantity and its effect on well-being, but the value of a consistent sleep routine remains ...
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Reliability of the saliva self-sampling with and without supervision
original article
embargoed access
published version
2023
,Acta Universitatis Carolinae. Kinanthropologica
,59
(1)
One of the least invasive sampling methods suitable for self-sampling is saliva spitting. The aim of this study is to evaluate the suitability of saliva self-sampling for unsupervised testing. Two self-sampling strategies ...
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Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
original article
open access
published version
2023
,Nature Communications
,14
(1)
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, ...
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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome
original article
open access
published version
2023
,Nature Communications
,14
(1)
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified ...
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STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
abstract in e-form
open access
accepted version
2023
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway plays a central role in recognition of the double-stranded DNA in cytoplasm, a sign of cell damage or infection. Upon activation, the pathway ...
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STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes
abstract in e-form
open access
accepted version
2023
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
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Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease
original article
open access
published version
2023
,NPJ Parkinsons Disease
,9
(1)
Oxidative stress supposedly plays a role in the pathogenesis of Parkinson's disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative ...
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Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder
original article
open access
published version
2023
,NPJ Parkinsons Disease
,9
(1)
REM sleep without atonia (RWA) is the hallmark of isolated REM sleep behavior disorder (iRBD) and is caused by neurodegeneration of brainstem structures. Previously, quantitative susceptibility mapping (QSM) was shown to ...
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Kapitoly z kreativní hudební výchovy
Chapters on Creative Music Education
schoolbook (tertiary education)
open access
published version
2023
,Praha
,Univerzita Karlova, Pedagogická fakulta
Vysokoškolská učebnice Kapitoly z kreativní hudební výchovy je publikačním výstupem projektu Kreativní interakce jako zdroj motivace a inovace ve výuce vysokoškolských pedagogů a v pregraduální přípravě pedagogů HV, ...
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Understanding the Effect of Aspartate Hydroxylase Inhibition On T Cell-Mediated Immunity Using Single-Cell RNA Sequencing
abstract in e-form
open access
accepted version
2023
,Neuvedeno
Overexpression of aspartate β-hydroxylase (ASPH) was found in 70-90% of solid tumors but is negligible in normal tissues. Increased ASPH contributes to tumor cell proliferation, migration, and invasion but can also affect ...
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Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
original article
open access
published version
2023
,Eurosurveillance
,28
(38)
Background: The sensitivity and specificity of selected antigen detection rapid diagnostic tests (AG-RDTs) for SARS-CoV-2 were determined in the unvaccinated population when the Delta variant was circulating. Viral loads, ...
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Human polyomaviruses in psoriasis patients on biologic treatment
abstract in e-form
open access
accepted version
2023
,Neuveden
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
