STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes

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Pimková Polidarová, MarkétaORCiD Profile - 0000-0003-3116-1328WoS Profile - V-2351-2017Scopus Profile - 57212310198
Hirsch, IvanORCiD Profile - 0000-0003-1701-1438WoS Profile - R-3103-2016Scopus Profile - 56275056800
Berehovska, Olena
Janovec, VáclavORCiD Profile - 0000-0002-6262-3364WoS Profile - N-7608-2017Scopus Profile - 57193086112
Brázdová, AndreaORCiD Profile - 0000-0002-2384-6012WoS Profile - DWY-2679-2022Scopus Profile - 36023303000
Grantz Šašková, KláraORCiD Profile - 0000-0003-2874-5699WoS Profile - E-1931-2014Scopus Profile - 22954587000
Hepatitis B Foundation

Publication date
2023
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Abstract
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells to secrete type I interferons (IFNs) andvarious proinflammatory cytokines. These immunomodulatory proteins further induce multipleregulatory immune processes with antiviral or antitumoral properties.
Keywords
STING, cyclic-GMP-AMP, agonist-treated
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https://hdl.handle.net/20.500.14178/2042
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