Repozitář publikační činnosti UK: Recent submissions
Now showing items 2181-2200 of 2209
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Methodological guidelines for open access and self-archiving at Charles University : Methodological guidelines for open access coordinators
Metodika open access a autoarchivace na Univerzitě Karlově : Metodika pro koordinátory open access
uncertified methodology
open access
draft
2022
,Praha
,Univerzita Karlova, Ústřední knihovna
Methodological guidelines for open access and self-archiving at Charles University : Methodological guidelines for open access coordinators is a document intended for CU employees (open access coordinators) who, in the OBD ...
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Pracovní právo a sociální ochrana v nejisté době
Labor law and social protection in uncertain times
collection of papers
embargoed access
published version
2022
,Praha
,Univerzita Karlova, Právnická fakulta
Kniha se zabývá aktuálním otázkami pracovního práva a sociální ochrany
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Lékaři 2022 aneb specializační vzdělávání očima lékařů
manual
open access
published version
2023
,Praha
,Univerzita Karlova, 3. lékařská fakulta
Průzkum je pokusem o to, aby byl slyšet hlas těch, kteří se specializačního vzdělávání přímo účastní. Je možné, že některé jeho části budou vnímány velmi problematicky či vzbudí řadu emocí. Byli bychom ale neradi, aby byl ...
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The demand side of vaccine politics and pandemic illiberalism
original article
open access
published version
2022
,East European Politics
,38
(4)
We take the demand-side perspective of Sputnik V, trying to answer why facing vaccine scarcity, some countries opt for Sputnik V, and others do not. To show how the pandemic tests the institutional safeguards and soft ...
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Role of actors in the processes of sustainable development at local level – experiences from the Czech Republic
original article
open access
published version
2022
,Frontiers in Sustainability [online]
,3
(07 July 2022)
In this text we are interested in the preconditions for, and opportunities provided by sustainable development at local level in non-metropolitan areas, i. e., in rural areas and villages. These areas are generally seen ...
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Local Action Groups and sustainable development agenda: Case study of regional perspectives from Czechia
original article
open access
published version
2022
,Frontiers in Sustainability [online]
,3
(22 July 2022)
The United Nations' 2030 Agenda for Sustainable Development is generally accepted as an overarching framework to cope with various global challenges. Many of them are manifested locally and need to be solved at the regional ...
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Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens
original article
open access
published version
2023
,Future Medicinal Chemistry
,15
(3)
Background: Increasing rates of acquired resistance have justified the critical need for novel antimicrobial drugs. One viable concept is the modification of known drugs. Methods & results: 21 mafenide-based compounds were ...
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Engine shutdown: Migrastatic strategies and prevention of metastases
summarizing article
embargoed access
published version
2023
,Trends in Cancer
,9
(4)
Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the ...
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Publication and Attenuation Biases in Measuring Skill Substitution
original article
embargoed access
submitted version
2024
,Review of Economics and Statistics
,106
(5)
A key parameter in the analysis of wage inequality is the elasticity of substitution between skilled and unskilled labor. We show that the empirical literature is consistent with both publication and attenuation bias in ...
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Low-Temperature Annealing of CdZnTeSe under Bias
original article
open access
published version
2022
,MDPI
,Sensors
,22
(1)
We performed a gradual low-temperature annealing up to 360 K on a CdZnTeSe radiation detector equipped with gold and indium electrodes under bias at both polarities. We observed significant changes in the detector's ...
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Projected changes in mean annual cycle of temperature and precipitation over the Czech Republic: Comparison of CMIP5 and CMIP6
original article
open access
published version
2022
,FRONTIERS MEDIA SA
,Frontiers in Earth Science [online]
,10
(6.10.2022)
The multi-model ensembles like CMIP5 or CMIP6 provide a tool to analyze structural uncertainty of climate simulations. Currently developed regional and local climate change scenarios for the Czech Republic assess the ...
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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunities
summarizing article
open access
published version
2022
,Cells
,11
(22)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, ...
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PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
original article
embargoed access
published version
2022
,Biomedicines
,10
(11)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
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Future changes in snowpack will impact seasonal runoff and low flows in Czechia
original article
open access
published version
2021
,Journal of Hydrology: Regional Studies [online]
,37
(October)
Study Region Central Europe, Czechia. Study Focus Mountains are referred to as "water towers" because they substantially affect the hydrology of downstream areas. However, snow storages will decrease in the future due to ...
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Electrophysiological and computational analysis of Ca(v)3.2 channel variants associated with familial trigeminal neuralgia
original article
embargoed access
published version
2022
,Molecular Brain
,15
(November)
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic ...
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Phlebovirus Transmission by Sand Flies
abstract in conference proceedings
open access
accepted version
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Arboviruses of the genus Phlebovirusare currently represented by 67 species found in Eurasia, Africa, and the Americas1. Although they have a great impact on human and animal health, information about their biology ...
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Transcription apparatus of the yeast virus-like elements is closely related to the poxviral transcription apparatus
abstract in conference proceedings
open access
published version
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
We employed virus-like elements (VLEs) pGKL1,2 from Kluyveromyces lactisas a model to investigate the previously neglected transcriptome of the broader group of yeast cytoplasmic linear dsDNA VLEs. We found that RNA ...
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Understanding the molecular mechanisms of viruses and host interactions
abstract in conference proceedings
open access
published version
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Our research is focused on two objectives, first, the study of interactions between nuclear proteins and viral components which could result in the restriction or establishment of the infection, and second, the elucidation ...
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Role of PML nuclear bodies during mouse polyomavirus infection: PML protein isoforms and the non-canonical histone H3.3
abstract in conference proceedings
open access
published version
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The possible restriction function of promyelocytic nuclear bodies (PML NBs) and their associated proteins in polyomavirus infection was studied. At first, We found that the absence of PML protein positively affects the ...
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Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA
abstract in conference proceedings
open access
published version
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
We previously described that Murine polyomavirus MPyV induces type I interferon (IFN) responses via the sensors, p204 (human IFI16 homolog) and cGAS which sense viral genomes and micronucleus-like bodies generated during ...
