• Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy 

  Dejmek, Milan; Brázdová, Andrea; Otava, Tomas; Pimková Polidarová, Markéta; Klima, Martin; Smola, Miroslav; Vavřina, Zdeněk; Budesinsky, Milos; Dracinsky, Martin; Liboska, Radek; Boura, Evzen; Birkus, Gabriel; Nencka, Radim (2023)

  Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell ...

• The crystal structure of bis(1H-pyrazole-carboxamidine-κN,N′)bis(nitrato-κO)-copper(II), C8H12CuN10O6 

  Kohúteková, Soňa; Matulková, Irena; Císařová, Ivana; Němec, Ivan (2023)

  C8H12CuN10O6, triclinic, P1 (no. 2), a = 7.6063(5) Å, b = 9.3072(7) Å, c = 10.8485(8) Å, alpha = 81.370(2)°, beta = 75.503(2)°, gamma = 84.756(2)° V = 733.97(9) Å(3), Z = 2, R-gt(F) = 0.0515, wR(ref)(F-2) = 0.1194, T =120(2) K.

• Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease 

  Zuna, Jan; Hovorková, Lenka; Krotká, Justina; Koehrmann, Amelie; Bardini, Michela; Winkowska, Lucie; Froňková, Eva; Alten, Julia; Koehler, Rolf; Eckert, Cornelia; Brizzolara, Lisa; Trkova, Marie; Stuchlý, Jan; Zimmermann, Martin; De Lorenzo, Paola; Valsecchi, Maria Grazia; Conter, Valentino; Starý, Jan; Schrappe, Martin; Biondi, Andrea; Trka, Jan; Žaliová, Markéta; Cazzaniga, Giovanni; Cario, Gunnar (2022)

  Recently, we defined "CML-like" subtype of BCR::ABL1-positive acute lymphoblastic leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here we retrospectively analyzed prognostic relevance ...

• Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy 

  Alquezar Artieda, Natividad; Kužílková, Daniela; Roberts, Jennie; Hložková, Kateřina; Pecinova, Alena; Pecina, Petr; Zwyrtková, Martina; Potůčková, Eliška; Kavan, Daniel; Heřmanová, Ivana; Žaliová, Markéta; Novák, Petr; Mracek, Tomas; Šrámková, Lucie; Tennant, Daniel A; Trka, Jan; Starková, Júlia (2023)

  L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse ...

• Ludwig von MISES: Socialismus: ekonomická a sociologická analýza 

  Skála, Marek (2023)

  Reflexe hospodářsko-historické analýzy socialistického systému. Zamyšlení nad jejím možným využitím historickou obcí v současné době.

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