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Loss of ADAR1 protein induces changes in small RNA landscape in hepatocytes
(2023)
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery and cellular antiviral response. It has been shown ...
The microenvironment of HPV-associated and HPV-negative oropharyngeal tumors
(Řím, 2023)
Patients with HPV-associated oropharyngeal tumors have a survival advantage. They have better treatment response and less frequently develop recurrence. This recognition led to the inclusion of the indirect marker of an ...
Transcripts of vaccinia virus postreplicative genes do not contain a 5' methylguanosine cap
(2023)
Vaccinia virus (VACV) is a prototypical poxvirus originally used for eradication of smallpox. Investigation into VACV mRNAs carried out almost half a century agosubstantially contributed to the fundamental discovery of the ...
STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths
(2023)
Double-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines ...
Specific Immune Response Against SARS-CoV-2
(2023)
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide. For effective treatment and introduction of appropriate antipandemic measures, it is necessary to understand the development ...
Human polyomaviruses in psoriasis patients on biologic treatment
(2023)
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
Understanding the Effect of Aspartate Hydroxylase Inhibition On T Cell-Mediated Immunity Using Single-Cell RNA Sequencing
(2023)
Overexpression of aspartate β-hydroxylase (ASPH) was found in 70-90% of solid tumors but is negligible in normal tissues. Increased ASPH contributes to tumor cell proliferation, migration, and invasion but can also affect ...
STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes
(2023)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
(2023)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway plays a central role in recognition of the double-stranded DNA in cytoplasm, a sign of cell damage or infection. Upon activation, the pathway ...
HBV-induced microenvironment reduces pDC response to TLR7/9 stimulation
(2023)
Hepatitis B virus (HBV) is an infectious agent that causes acute hepatitis, but can also leadto chronic inflammation, and, consequently, to hepatocellular carcinoma. HBV is described as"stealth virus", since it avoids ...