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STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths
(2023)
Double-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines ...
STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes
(2023)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
(2023)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway plays a central role in recognition of the double-stranded DNA in cytoplasm, a sign of cell damage or infection. Upon activation, the pathway ...
The Interplay between Viruses and Host DNA Sensors
(2022)
DNA virus infections are often lifelong and can cause serious diseases in their hosts. Their recognition by the sensors of the innate immune system represents the front line of host defence. Understanding the molecular ...
STING agonists activate multiple regulated cell death mechanisms in monocytes
(2023)
Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases, such as cancer or chronic ...
Bioinformatics analysis of immune characteristics in tumors with alternative carcinogenesis pathways induced by human papillomaviruses
(2023)
Human papillomaviruses (HPVs) induce a subset of head and neck squamous cell carcinomas (HNSCC) and anogenital cancers, particularly cervical cancer (CC). The major viral proteins that contribute to tumorigenesis are the ...
DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
(Nizozemsko, 2024)
Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ...
STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
(Nizozemsko, 2024)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ...
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
(2023)
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell ...