STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation

Abstract

The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production of proinflammatory cytokines byimmune cells that then modulate subsequent immune responses with antiviral and antitumoralproperties. Consequently, compounds that activate the cGAS-STING pathway are oftherapeutic interest.We recently described that STING agonists also trigger cell death of monocytes. Therefore,we characterized monocyte cell death in terms of apoptosis, pyroptosis and necroptosis.