dc.contributor.author | Pimková Polidarová, Markéta | |
dc.contributor.author | Brázdová, Andrea | |
dc.contributor.author | Hirsch, Ivan | |
dc.contributor.author | Grantz Šašková, Klára | |
dc.date.accessioned | 2024-04-29T10:10:39Z | |
dc.date.available | 2024-04-29T10:10:39Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2423 | |
dc.description.abstract | The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production of proinflammatory cytokines byimmune cells that then modulate subsequent immune responses with antiviral and antitumoralproperties. Consequently, compounds that activate the cGAS-STING pathway are oftherapeutic interest.We recently described that STING agonists also trigger cell death of monocytes. Therefore,we characterized monocyte cell death in terms of apoptosis, pyroptosis and necroptosis. | en |
dc.language.iso | en | |
dc.relation.url | https://www.toll2024.org/abstract-e-book/ | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-04-29T10:10:39Z | |
dc.subject.keyword | cGAS | en |
dc.subject.keyword | STING | en |
dc.subject.keyword | cytokines | en |
dc.subject.keyword | regulated cell death | en |
dc.subject.keyword | monocytes | en |
dc.publisher.publicationPlace | Nizozemsko | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2024-04-29 | |
dc.contributor.organizer | Kenes Group | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | |
dc.identifier.obd | 647263 | |
dc.subject.rivPrimary | 10000::10600 | |
dcterms.isPartOf.name | TOLL 2024 Road to translation | |
dcterms.isPartOf.journalYear | 2024 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | TOLL 2024 | |
dc.description.pageRange | 119-119 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
dc.type.obdHierarchyCode | 110::130::462 | en |
uk.displayTitle | STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation | en |