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STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation

dc.contributor.authorPimková Polidarová, Markéta
dc.contributor.authorBrázdová, Andrea
dc.contributor.authorHirsch, Ivan
dc.contributor.authorGrantz Šašková, Klára
dc.date.accessioned2024-04-29T10:10:39Z
dc.date.available2024-04-29T10:10:39Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2423
dc.description.abstractThe cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production of proinflammatory cytokines byimmune cells that then modulate subsequent immune responses with antiviral and antitumoralproperties. Consequently, compounds that activate the cGAS-STING pathway are oftherapeutic interest.We recently described that STING agonists also trigger cell death of monocytes. Therefore,we characterized monocyte cell death in terms of apoptosis, pyroptosis and necroptosis.en
dc.language.isoen
dc.relation.urlhttps://www.toll2024.org/abstract-e-book/
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleSTING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activationen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-04-29T10:10:39Z
dc.subject.keywordcGASen
dc.subject.keywordSTINGen
dc.subject.keywordcytokinesen
dc.subject.keywordregulated cell deathen
dc.subject.keywordmonocytesen
dc.publisher.publicationPlaceNizozemsko
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5103
dc.date.embargoStartDate2024-04-29
dc.contributor.organizerKenes Group
dc.type.obd110
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.obd647263
dc.subject.rivPrimary10000::10600
dcterms.isPartOf.nameTOLL 2024 Road to translation
dcterms.isPartOf.journalYear2024
uk.faculty.primaryId115
uk.faculty.primaryNamePřírodovědecká fakultacs
uk.faculty.primaryNameFaculty of Scienceen
uk.department.primaryId1034
uk.department.primaryNameKatedra genetiky a mikrobiologiecs
uk.department.primaryNameDepartment of Genetics and Microbiologyen
uk.event.nameTOLL 2024
dc.description.pageRange119-119
dc.type.obdHierarchyCsABSTRAKT::abstrakt::abstrakt v konferenčním sborníkucs
dc.type.obdHierarchyEnABSTRACT::abstract::abstract in conference proceedingsen
dc.type.obdHierarchyCode110::130::462en
uk.displayTitleSTING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activationen


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