dc.contributor.author | Šimják, Patrik | |
dc.contributor.author | Petr, Tomáš | |
dc.contributor.author | Kaslová, Barbora | |
dc.contributor.author | Fejfar, Tomáš | |
dc.contributor.author | Hůlek, Petr | |
dc.contributor.author | Pařízek, Antonín | |
dc.contributor.author | Vítek, Libor | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1698 | |
dc.description.abstract | In the literature on the safety of ursodeoxycholic acid (UDCA) during breastfeeding, insufficient data has been reported to date. Thus, the aim of our study was to analyze bile acid (BA) concentrations in breast milk in a cohort of patients, treated with UDCA, and with various cholestatic liver diseases. The study was carried out on a cohort of 20 patients with various cholestatic diseases. All the patients were treated with UDCA (500-1500 mg daily). Concentrations of BA, sampled on day 3 after delivery were analyzed using the GS-MS technique, and then compared to untreated women. Total BA concentrations in the breast milk of the UDCA-treated patients were equal to those of the untreated women controls (3.2 +/- 1 vs. 3.2 +/- 0.2 mu mol/L, respectively). The UDCA concentrations in breast milk remained negligible in UDCA-treated patients (0.69 mu mol/L), and in any event did not contribute to the newborn BA pool. No apparent side-effects of the maternal UDCA treatment were observed in any newborn infant, and no deterioration in postnatal development was observed during the routine 1-year follow-ups. Therapeutic administration of UDCA during lactation is safe for breastfed babies since UDCA only gets into breast milk in negligible amounts. UDCA treatment should be allowed and included into the guidelines for the therapy of cholestatic diseases in breastfeeding mothers. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1038/s41598-022-24253-y | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:12:53Z | |
dc.subject.keyword | ursodeoxycholic acid | en |
dc.subject.keyword | lactation | en |
dc.subject.keyword | breast milk | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/RVO-VFN64165 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5104 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNHK | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1038/s41598-022-24253-y | |
dc.identifier.utWos | 000885139000009 | |
dc.identifier.eidScopus | 2-s2.0-85141826181 | |
dc.identifier.obd | 618567 | |
dc.identifier.riv | RIV/00216208:11150/22:10450908 | |
dc.identifier.riv | RIV/00216208:11110/22:10450908 | |
dc.identifier.riv | RIV/00179906:_____/22:10450908 | |
dc.identifier.riv | RIV/00064165:_____/22:10450908 | |
dc.identifier.pubmed | 36379995 | |
dc.subject.rivPrimary | 30000::30200::30219 | |
dcterms.isPartOf.name | Scientific Reports | |
dcterms.isPartOf.issn | 2045-2322 | |
dcterms.isPartOf.journalYear | 2022 | |
dcterms.isPartOf.journalVolume | 12 | |
dcterms.isPartOf.journalIssue | 1 | |
uk.faculty.primaryId | 108 | |
uk.faculty.primaryName | 1. lékařská fakulta | cs |
uk.faculty.primaryName | First Faculty of Medicine | en |
uk.faculty.secondaryId | 51 | |
uk.faculty.secondaryId | 53 | |
uk.faculty.secondaryId | 112 | |
uk.faculty.secondaryName | Fakultní nemocnice Hradec Králové | cs |
uk.faculty.secondaryName | University Hospital Hradec Králové | en |
uk.faculty.secondaryName | Všeobecná fakultní nemocnice v Praze | cs |
uk.faculty.secondaryName | Všeobecná fakultní nemocnice v Praze | en |
uk.faculty.secondaryName | Lékařská fakulta v Hradci Králové | cs |
uk.faculty.secondaryName | Faculty of Medicine in Hradec Kralove | en |
uk.department.primaryId | 1507 | |
uk.department.primaryName | Klinika gynekologie, porodnictví a neonatologie 1. LF UK a VFN | cs |
uk.department.primaryName | Department of Gynaecology, Obstetrics and Neonatology | en |
uk.department.secondaryId | 1520 | |
uk.department.secondaryId | 5000002601 | |
uk.department.secondaryId | 5000002593 | |
uk.department.secondaryId | 1538 | |
uk.department.secondaryId | 5000002628 | |
uk.department.secondaryId | 930 | |
uk.department.secondaryId | 5000000005 | |
uk.department.secondaryName | IV. interní klinika – klinika gastroenterologie a hepatologie 1. LF UK a VFN | cs |
uk.department.secondaryName | 4th Department of Medicine Department of Gastroenterology and Hepatology | en |
uk.department.secondaryName | IV. interní klinika - klinika gastroenterologie a hepatologie 1.LF a VFN | cs |
uk.department.secondaryName | IV. interní klinika - klinika gastroenterologie a hepatologie 1.LF a VFN | en |
uk.department.secondaryName | Gynekologicko-porodnická klinika 1.LF a VFN | cs |
uk.department.secondaryName | Gynekologicko-porodnická klinika 1.LF a VFN | en |
uk.department.secondaryName | Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN | cs |
uk.department.secondaryName | Institute of Medical Biochemistry and Laboratory Diagnostics | en |
uk.department.secondaryName | Ústav lékařské biochemie a laboratorní diagnostiky 1.LF a VFN | cs |
uk.department.secondaryName | Ústav lékařské biochemie a laboratorní diagnostiky 1.LF a VFN | en |
uk.department.secondaryName | II. interní gastroenterologická klinika | cs |
uk.department.secondaryName | 2nd Department of Internal Medicine – Gastroenterology | en |
uk.department.secondaryName | II. interní gastroenterologická klinika | cs |
uk.department.secondaryName | The 2nd Department of Internal Medicne - Gastroenterology | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk | en |