Engine shutdown: Migrastatic strategies and prevention of metastases

Autor
Raudenská, Martina
Petrláková, Kateřina
Juriňáková, Tamara
Leischner Fialová, Jindřiška
Fojtů, Michaela
Datum vydání
2023Publikováno v
Trends in CancerRočník / Číslo vydání
9 (4)ISBN / ISSN
ISSN: 2405-8033ISBN / ISSN
eISSN: 2405-8025Metadata
Zobrazit celý záznamKolekce
Tato publikace má vydavatelskou verzi s DOI 10.1016/j.trecan.2023.01.001
Abstrakt
Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the migration machinery has been shown to promote metastatic dissemination, successful migrastatic therapy may reduce the need for high-dose cytotoxic therapies that are currently used to prevent the risk of metastatic dissemination. In this review we focus on anti-invasive and antimetastatic strategies that hold promise for the treatment of solid tumors. The best targets for migrastatic therapy would be those that are required by all forms of motility, such as ATP availability, mitochondrial metabolism, and cytoskeletal dynamics and cell contractility.
Klíčová slova
cancer, cancer therapy, cell migration, metastasis, migrastatic therapy, mitochondria-targeting therapy, nanocarriers
Trvalý odkaz
https://hdl.handle.net/20.500.14178/1810Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ 4.0 International