dc.contributor.author | Chalupová, Miroslava | |
dc.contributor.author | Horák, Jan | |
dc.contributor.author | Kramná, Lenka | |
dc.contributor.author | Nalos, Lukáš | |
dc.contributor.author | Štengl, Milan | |
dc.contributor.author | Chudějová, Kateřina | |
dc.contributor.author | Kraftová, Lucie | |
dc.contributor.author | Cinek, Ondřej | |
dc.contributor.author | Klein, Pavel | |
dc.contributor.author | Matějovič, Martin | |
dc.contributor.author | Hrabák, Jaroslav | |
dc.contributor.editor | Šímová, Šárka | |
dc.date.accessioned | 2023-06-30T06:41:35Z | |
dc.date.available | 2023-06-30T06:41:35Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1966 | |
dc.description.abstract | Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the host response has been observed among animals. Thus, there is astrong demand to better understand the potential sources of this heterogeneity. In this study, we compared faecal microbiome composition of 12 animals. Three samples were collected at different time points from each animal. Bacteriome was subjected to 16S rDNA profiling. Asignificant difference in bacterial composition was associated with the season (p<0.001) but not with the sex of the pig (p = 0.28), the timing of sample collection (p = 0.59), or interactions thereof (all p > 0.3). The seasonbatchexplained 55% of the total variance in the bacteriome diversity. The seasonterm was highly significant from the high-resolution level of the bacterial amplicon sequencing variants up to the level of phylum. The diversity of the microbiome composition could significantly influence experimental model of sepsis, and studies are warranted to demonstrate the effects of gut microbiome diversity on the host-response. If confirmed, control of the gut microbiome should become a standard part of the pre-clinical sepsis experiments. | en |
dc.language.iso | en | |
dc.relation.url | http://www.ccsss.cz/index.php/ccsss/issue/view/37/67 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis | en |
dcterms.accessRights | embargoedAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:16:26Z | |
dc.subject.keyword | microbiome | en |
dc.subject.keyword | sepsis, porcine model | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MZ0/NV/NV17-29239A | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM/EF/EF16_019/0000787 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.date.embargoEndDate | 2023-06-28 | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.obd | 633070 | |
dc.subject.rivPrimary | 30000::30300::30303 | |
dcterms.isPartOf.name | Czech Chemical Society Symposium Series | |
dcterms.isPartOf.issn | 2336-7202 | |
dcterms.isPartOf.journalYear | 2022 | |
dcterms.isPartOf.journalVolume | 20 | |
dcterms.isPartOf.journalIssue | 6 | |
uk.faculty.primaryId | 111 | |
uk.faculty.primaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.primaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryId | 109 | |
uk.faculty.secondaryId | 52 | |
uk.faculty.secondaryName | 2. lékařská fakulta | cs |
uk.faculty.secondaryName | Second Faculty of Medicine | en |
uk.faculty.secondaryName | Fakultní nemocnice v Motole | cs |
uk.faculty.secondaryName | Motol University Hospital | en |
uk.department.primaryId | 100012968318 | |
uk.department.primaryName | Biomedicínské centrum | cs |
uk.department.primaryName | Biomedical Center | en |
uk.department.secondaryId | 1435 | |
uk.department.secondaryId | 100010693530 | |
uk.department.secondaryId | 1685 | |
uk.department.secondaryId | 1391 | |
uk.department.secondaryId | 1351 | |
uk.department.secondaryId | 1359 | |
uk.department.secondaryName | Stomatologická klinika | cs |
uk.department.secondaryName | Department of Stomatology | en |
uk.department.secondaryName | Pediatrická klinika 2. LF UK a FN Motol | cs |
uk.department.secondaryName | Department of Paediatrics, 2nd Faculty of Medicine and Motol University Hospital | en |
uk.department.secondaryName | Pediatrická klinika | cs |
uk.department.secondaryName | Pediatrická klinika | en |
uk.department.secondaryName | I.Interní klinika | cs |
uk.department.secondaryName | Department of Internal Medicine I | en |
uk.department.secondaryName | Ústav fyziologie | cs |
uk.department.secondaryName | Department of Physiology | en |
uk.department.secondaryName | Ústav mikrobiologie | cs |
uk.department.secondaryName | Department of Microbiology | en |
uk.event.name | The first annual meeting of the National Institute of Virology and Bacteriology | |
dc.description.pageRange | 402-403 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
dc.type.obdHierarchyCode | 110::130::462 | en |
uk.displayTitle | Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis | en |