Role of the PML nuclear bodies and its associated histones chaperones in the remodeling of mouse polyomavirus minichromosomes

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Author
Rjabčenko, BorisORCiD Profile - 0000-0001-7076-256XWoS Profile - U-8964-2017Scopus Profile - 36142246600
Satratzemis, Christos
Forstová, JitkaORCiD Profile - 0000-0003-0219-506XWoS Profile - L-7328-2017Scopus Profile - 6701385419
Huerfano Meneses, SandraORCiD Profile - 0000-0001-5221-3014WoS Profile - G-8469-2013Scopus Profile - 6506988916
Šímová, Šárka

Publication date
2023
Published in
Czech Chemical Society Symposium Series
Volume / Issue
21 (5)
ISBN / ISSN
ISSN: 2336-7202
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Abstract
Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of infection. In the mouse polyomavirus (MPyV) virions, the circular dsDNA genome and cellular histones are present in the form of a condensed minichromosome arranged into 24 nucleosomes. Here we studied the contribution of PML NBs and their chaperone complexes HIRA and ATRX/DAXX in remodeling MPyV chromatin.
Keywords
Polyomavirus, cell, HIRA, ATRX/DAXX
Permanent link
https://hdl.handle.net/20.500.14178/2065
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