PML nuclear bodies orchestrate antiviral response in HBV-infected hepatocytes

Autor
Lubyová, Barbora
Datum vydání
2023Publikováno v
Czech Chemical Society Symposium SeriesRočník / Číslo vydání
21 (5)ISBN / ISSN
ISSN: 2336-7202Metadata
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Abstrakt
Promyelocytic leukaemia nuclear bodies (PML-NBs) play roles in various cellular functions and represent a key component of antiviral defense. In the case of hepatitis B virus (HBV), the antiviral activity of PML-NBs has been associated with the presence of SMC5/6 and epigenetic silencing of cccDNA. However, PML-NBs can have apleiotropic effect on the life cycle of HBV and the role of PML-NBs needs to be further elucidated.
Klíčová slova
PML-NBs, HepG2-NTCP
Trvalý odkaz
https://hdl.handle.net/20.500.14178/2067Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ 4.0 International