Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

Autor
Siegl, Frantisek
Datum vydání
2024Publikováno v
Biomarker ResearchRočník / Číslo vydání
12 (1)ISBN / ISSN
ISSN: 2050-7771Metadata
Zobrazit celý záznamKolekce
Tato publikace má vydavatelskou verzi s DOI 10.1186/s40364-024-00563-3
Abstrakt
Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.
Klíčová slova
Cancer, Cancer stem cells, PIWI proteins, PIWI-interacting RNAs, piRNAs
Trvalý odkaz
https://hdl.handle.net/20.500.14178/2240Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ 4.0 International