dc.contributor.author | Horníková, Lenka | |
dc.contributor.author | Lišková, Jitka | |
dc.contributor.author | Šnejdarová, Aneta | |
dc.contributor.author | Huerfano Meneses, Sandra | |
dc.date.accessioned | 2024-07-25T09:46:09Z | |
dc.date.available | 2024-07-25T09:46:09Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2560 | |
dc.description.abstract | Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses resulted in cGAS-STING pathway activation but only moderate interferon beta production was detected indicating possible regulation of the pathway during the infection. STING is a transmembrane protein that predominantly resides in the endoplasmic reticulum (ER). After binding to cGAMP di-nucleotide, STING oligomerizes. Oligomers translocate from ER to trans Golgi reticulum which leads to TBK1 and IRF3 phosphorylation and subsequent interferon-beta production. Later, STING is degraded in proteasomes or autophagosomes. | en |
dc.language.iso | en | |
dc.publisher | Gianni Cinello, Lithostampa SrL, Udine | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | STING regulation in polyomavirus infections | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-07-25T09:46:09Z | |
dc.subject.keyword | STING | en |
dc.subject.keyword | polyomavirus | en |
dc.subject.keyword | infection | en |
dc.publisher.publicationPlace | Itálie | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2024-07-25 | |
dc.contributor.organizer | International Centre for Genetic Engineering and Biotechnology | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.obd | 649747 | |
dc.subject.rivPrimary | 10000::10600::10607 | |
dcterms.isPartOf.name | ICGEB DNA Tumour Virus Meeting | |
dcterms.isPartOf.journalYear | 2024 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | ICGEB DNA Tumour Virus Meeting | |
dc.description.pageRange | 135-135 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v elektronické podobě | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in e-form | en |
dc.type.obdHierarchyCode | 110::130::136 | en |
uk.displayTitle | STING regulation in polyomavirus infections | en |