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Muscle Lipid Oxidation Is Not Affected by Obstructive Sleep Apnea in Diabetes and Healthy Subjects
(2023)
The molecular mechanisms linking obstructive sleep apnea (OSA) with type 2 diabetes mellitus (T2DM) remain unclear. This study investigated the effect of OSA on skeletal muscle lipid oxidation in nondiabetic controls and ...
Acute ischaemic stroke: recent advances in reperfusion treatment
(2023)
During the last 5-7 years, tremendous progress was achieved in the reperfusion treatment of acute ischaemic stroke during its first few hours from symptom onset. This review summarizes the latest evidence from randomized ...
Left ventricular resynchronization with left bundle branch area pacing: does the type of capture matter?
(2023)
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) has been a mainstream treatment in heart failure patients with wide QRS complexes for two decades. In recent years, left bundle branch pacing (LBBP) ...
Left ventricular septal pacing - can we trust the ECG?
(2023)
In contrast to left bundle branch pacing, the criteria for left ventricular septal pacing (LVSP) were never validated. LVSP is usually defined as deep septal deployment of the pacing lead with a pseudo-right bundle branch ...
Resynchronization for shifting conduction patterns - When a coronary sinus lead is not enough
(2023)
A 60-year-old patient with heart failure (NYHA II) due to non-ischemic cardiomyopathy with a left ventricular end-diastolic diameter (LVEDD) of 73 mm and left ventricular ejection fraction (LVEF) 20% presented with ...
Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre
(2023)
A unique clinical feature of Takotsubo syndrome (TTS) is the stress trigger factor. Different types of triggers exist, generally divided into emotional and physical stressor. The aim was to create long-term registry of all ...
Implication of different replicons in the spread of the VIM-1-encoding integron, In110, in Enterobacterales from Czech hospitals
(2023)
Background: VIM metallo-β-lactamases are enzymes characterized by the ability to hydrolyze all β-lactams. Usually, blaVIM-like genes are carried by class 1 integrons. In the Czech Republic, only sporadic cases of VIM-producing ...
Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding
(2023)
The association between antithrombotics (ATs) and the risk of gastrointestinal bleeding is well known; however, data regarding the influence of ATs on outcomes are scarce. The goals of this study are: (i) to assess the ...
Lékaři 2022 aneb specializační vzdělávání očima lékařů
(Univerzita Karlova, 3. lékařská fakulta, Praha, 2023)
Průzkum je pokusem o to, aby byl slyšet hlas těch, kteří se specializačního vzdělávání přímo účastní. Je možné, že některé jeho části budou vnímány velmi problematicky či vzbudí řadu emocí. Byli bychom ale neradi, aby byl ...
Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
(2023)
BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...