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ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
(2023)
A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant ...
MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes
(2023)
MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ...
Transseptal puncture in left atrial appendage closure guided by 3D printing and multiplanar CT reconstruction
(2023)
BACKGROUND: The presented study investigates the application of bi-arterial 3D printed models to guide transseptal puncture (TSP) in left atrial appendage closure (LAAC). AIMS: The objectives are to (1) test the feasibility ...
Nutritional practices and experiences of people on vegan diet with healthcare system: a qualitative study
(2023)
OBJECTIVES: The growing popularity of diets that restrict the consumption of animal-based foods is an important new challenge for the public healthcare system in Czechia. While the environmental and health-related benefits ...
Atrial fibrillation therapy and stroke prevention in hemodialysis patients
(2023)
The prevalence of atrial fibrillation (AF) in patients with chronic kidney disease (CKD), especially on hemodialysis (HD) is higher compared to the general population without CKD and reaches ~20%. The risk of ischemic ...
Frentizole derivatives with mTOR inhibiting and senomorphic properties
(2023)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole's potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in ...
Muscle Lipid Oxidation Is Not Affected by Obstructive Sleep Apnea in Diabetes and Healthy Subjects
(2023)
The molecular mechanisms linking obstructive sleep apnea (OSA) with type 2 diabetes mellitus (T2DM) remain unclear. This study investigated the effect of OSA on skeletal muscle lipid oxidation in nondiabetic controls and ...
Acute ischaemic stroke: recent advances in reperfusion treatment
(2023)
During the last 5-7 years, tremendous progress was achieved in the reperfusion treatment of acute ischaemic stroke during its first few hours from symptom onset. This review summarizes the latest evidence from randomized ...
Electrophysiological and computational analysis of Ca(v)3.2 channel variants associated with familial trigeminal neuralgia
(2022)
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic ...
T-wave inversions during conduction system pacing: A marker of more physiological ventricular activation
(2022)
Permanent myocardial pacing can preserve adequate heart rates and improve symptoms and mortality in patients with bradycardia. Conventional right ventricular (RV) pacing is far from the optimal treatment since up to 20% ...