3. Faculty of Medicine: Recent submissions
Now showing items 21-40 of 49
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Targets for pollutants in rat and human pancreatic beta-cells: The effect of prolonged exposure to sub-lethal concentrations of hexachlorocyclohexane isomers on the expression of function- and survival-related proteins
original article
open access
published version
2023
,Environmental Toxicology and Pharmacology
,104
(November)
Decades after most countries banned hexachlorocyclohexane, HCH isomers still pollute the environment. Many studies described HCH as a pro-diabetic factor; nevertheless, the effect of HCH isomers on pancreatic beta-cells ...
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Muscle Lipid Oxidation Is Not Affected by Obstructive Sleep Apnea in Diabetes and Healthy Subjects
original article
open access
published version
2023
,International Journal of Molecular Sciences
,24
(6)
The molecular mechanisms linking obstructive sleep apnea (OSA) with type 2 diabetes mellitus (T2DM) remain unclear. This study investigated the effect of OSA on skeletal muscle lipid oxidation in nondiabetic controls and ...
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Is it a true left bundle branch block or not?
letter to the editors
open access
published version
2023
,Journal of Interventional Cardiac Electrophysiology
,66
(6)
Among patients with wide QRS complexes of nonRBBB morphologies on ECG, there are those with preserved left septal Purkinje activation, i.e., intraventricular conduction delay (IVCD). Unfortunately, twelve lead ECGs do not ...
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Left ventricular resynchronization with left bundle branch area pacing: does the type of capture matter?
editorial
open access
published version
2023
,Europace
,25
(6)
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) has been a mainstream treatment in heart failure patients with wide QRS complexes for two decades. In recent years, left bundle branch pacing (LBBP) ...
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Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing
original article
open access
published version
2023
,Frontiers in Cardiovascular Medicine
,10
(March)
BACKGROUND: Left bundle branch pacing (LBBP) produces delayed, unphysiological activation of the right ventricle. Using ultra-high-frequency electrocardiography (UHF-ECG), we explored how bipolar anodal septal pacing with ...
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Transseptal puncture in left atrial appendage closure guided by 3D printing and multiplanar CT reconstruction
original article
open access
published version
2023
,Catheterization and Cardiovascular Interventions
,102
(7)
BACKGROUND: The presented study investigates the application of bi-arterial 3D printed models to guide transseptal puncture (TSP) in left atrial appendage closure (LAAC). AIMS: The objectives are to (1) test the feasibility ...
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Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials
original article
open access
published version
2023
,Frontiers in Cardiovascular Medicine
,9
(January)
Background: Sex- and gender-associated differences determine the disease response to treatment.Aim: The study aimed to explore the hypothesis that progress in the management of STE-myocardial infarction (STEMI) overcomes ...
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Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
original article
open access
published version
2023
,In Vivo
,37
(5)
BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...
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Human polyomaviruses in psoriasis patients on biologic treatment
abstract in e-form
open access
accepted version
2023
,Neuveden
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
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Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer
original article
open access
accepted version
2023
,Molecular Oncology
,17
(10)
Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling ...
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Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?
original article
open access
accepted version
2023
,Genes, Chromosomes & Cancer
,62
(12)
Rhabdomyosarcomas (RMS) constitute a heterogeneous spectrum of tumors with respect to clinical behavior and tumor morphology. The paternal uniparental disomy (pUPD) of 11p15.5 is a molecular change described mainly in ...
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Sborník materiálů z replikace výzkumné studie RN4CAST: Modul Evidence Based Practice ve výuce ošetřovatelské péče
Proceedings of the Replication of the RN4CAST Research Study: Evidence Based Practice Module in Nursing Education
collection of papers
embargoed access
published version
2023
,Praha
,Univerzita Karlova, 3. lékařská fakulta, Ústav ošetřovatelství
Sborník představuje historii tvorby a realizace projektu Modul Evidence based practice ve výuce ošetřovatelské péče v letech 2017-2022. Sborník obsahuje čtyři hlavní okruhy, které byly v pilotním projektu ověřené prakticky ...
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Epidemic spread of KPC-producing bacteria in the Czech Republic
abstract in conference proceedings
embargoed access
published version
2022
,Czech Chemical Society Symposium Series
,20
(6)
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
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MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes
original article
open access
published version
2023
,Oncology Letters
,25
(2)
MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ...
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Prevalence of myocardial injury in patients after acute ischaemic stroke according to standard criteria
original article
open access
published version
2023
,European Heart Journal: Supplements
,25
(Suppl. E)
This study examined the prevalence of acute and chronic myocardial injury according to standard criteria in patients after acute ischaemic stroke (AIS) and its relation to stroke severity and short-term prognosis. Between ...
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Pre-hospital delay, clinical characteristics, angiographic findings, and in-hospital mortality in young and middle-aged adults with acute coronary syndrome: a single-centre registry analysis
original article
open access
published version
2023
,European Heart Journal: Supplements
,25
(Suppl. E)
There are several differences between younger and older adults with acute coronary syndrome (ACS). However, few studies have evaluated these differences. We analysed the pre-hospital time interval [symptom onset to first ...
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Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding
original article
open access
published version
2023
,European Heart Journal: Supplements
,25
(Suppl. E)
The association between antithrombotics (ATs) and the risk of gastrointestinal bleeding is well known; however, data regarding the influence of ATs on outcomes are scarce. The goals of this study are: (i) to assess the ...
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Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre
original article
open access
published version
2023
,European Heart Journal: Supplements
,25
(Suppl. E)
A unique clinical feature of Takotsubo syndrome (TTS) is the stress trigger factor. Different types of triggers exist, generally divided into emotional and physical stressor. The aim was to create long-term registry of all ...
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Freedom as an Aim of Education
editorial
embargoed access
published version
2022
,Theology and Philosophy of Education [online]
,1
(2)
This is the second editorial of the first volume of the journal Theology and Philosophy of Education. The title of this editorial shows what could be seen as a common topic for all of the articles published in this second ...
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AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
original article
open access
submitted version
2022
,bioRxiv
,PREPRINT
This article is a preprint and has not been certified by peer review.
