3. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 21-40 z 45
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Transseptal puncture in left atrial appendage closure guided by 3D printing and multiplanar CT reconstruction
(2023)BACKGROUND: The presented study investigates the application of bi-arterial 3D printed models to guide transseptal puncture (TSP) in left atrial appendage closure (LAAC). AIMS: The objectives are to (1) test the feasibility ... -
Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials
(2023)Background: Sex- and gender-associated differences determine the disease response to treatment.Aim: The study aimed to explore the hypothesis that progress in the management of STE-myocardial infarction (STEMI) overcomes ... -
Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
(2023)BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ... -
Human polyomaviruses in psoriasis patients on biologic treatment
(2023)Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ... -
Frentizole derivatives with mTOR inhibiting and senomorphic properties
(2023)Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole's potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in ... -
Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer
(2023)Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling ... -
Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?
(2023)Rhabdomyosarcomas (RMS) constitute a heterogeneous spectrum of tumors with respect to clinical behavior and tumor morphology. The paternal uniparental disomy (pUPD) of 11p15.5 is a molecular change described mainly in ... -
Sborník materiálů z replikace výzkumné studie RN4CAST: Modul Evidence Based Practice ve výuce ošetřovatelské péče
(Univerzita Karlova, 3. lékařská fakulta, Ústav ošetřovatelství, Praha, 2023)Sborník představuje historii tvorby a realizace projektu Modul Evidence based practice ve výuce ošetřovatelské péče v letech 2017-2022. Sborník obsahuje čtyři hlavní okruhy, které byly v pilotním projektu ověřené prakticky ... -
Epidemic spread of KPC-producing bacteria in the Czech Republic
(2022)Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ... -
MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes
(2023)MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ... -
Prevalence of myocardial injury in patients after acute ischaemic stroke according to standard criteria
(2023)This study examined the prevalence of acute and chronic myocardial injury according to standard criteria in patients after acute ischaemic stroke (AIS) and its relation to stroke severity and short-term prognosis. Between ... -
Pre-hospital delay, clinical characteristics, angiographic findings, and in-hospital mortality in young and middle-aged adults with acute coronary syndrome: a single-centre registry analysis
(2023)There are several differences between younger and older adults with acute coronary syndrome (ACS). However, few studies have evaluated these differences. We analysed the pre-hospital time interval [symptom onset to first ... -
Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding
(2023)The association between antithrombotics (ATs) and the risk of gastrointestinal bleeding is well known; however, data regarding the influence of ATs on outcomes are scarce. The goals of this study are: (i) to assess the ... -
Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre
(2023)A unique clinical feature of Takotsubo syndrome (TTS) is the stress trigger factor. Different types of triggers exist, generally divided into emotional and physical stressor. The aim was to create long-term registry of all ... -
Freedom as an Aim of Education
(2022)This is the second editorial of the first volume of the journal Theology and Philosophy of Education. The title of this editorial shows what could be seen as a common topic for all of the articles published in this second ... -
AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
(2022)This article is a preprint and has not been certified by peer review. -
Approaches to Measuring the Activity of Major Lipolytic and Lipogenic Enzymes In Vitro and Ex Vivo
(2022)Since the 1950s, one of the goals of adipose tissue research has been to determine lipolytic and lipogenic activity as the primary metabolic pathways affecting adipocyte health and size and thus representing potential ... -
T-wave inversions during conduction system pacing: A marker of more physiological ventricular activation
(2022)Permanent myocardial pacing can preserve adequate heart rates and improve symptoms and mortality in patients with bradycardia. Conventional right ventricular (RV) pacing is far from the optimal treatment since up to 20% ... -
Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome
(2022)Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. ... -
Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register
(2022)OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...