Faculty of Science: Recent submissions
Now showing items 81-100 of 211
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Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
original article
open access
published version
2023
,European Journal of Medicinal Chemistry
,259
(November)
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell ...
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The crystal structure of bis(1H-pyrazole-carboxamidine-κN,N′)bis(nitrato-κO)-copper(II), C8H12CuN10O6
original article
restricted access
published version
2023
,Zeitschrift für Kristallographie - New Crystal Structures
,238
(2)
C8H12CuN10O6, triclinic, P1 (no. 2), a = 7.6063(5) Å, b = 9.3072(7) Å, c = 10.8485(8) Å, alpha = 81.370(2)°, beta = 75.503(2)°, gamma = 84.756(2)° V = 733.97(9) Å(3), Z = 2, R-gt(F) = 0.0515, wR(ref)(F-2) = 0.1194, T =120(2) K.
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Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
letter to the editors
restricted access
published version
2023
,Blood Advances
,7
(10)
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse ...
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R-Type Fonticins Produced by Pragia fontium Form Large Pores with High Conductance
original article
embargoed access
published version
2023
,Journal of Bacteriology
,205
(1)
Fonticins are phage tail-like bacteriocins produced by the Gram-negative bacterium Pragia fontium from the family Budviciaceae. This bacterium produces contractile-type particles that adsorb on the surface of sensitive ...
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The role of cohorts in the understanding of the changes in fertility in Czechia since 1990
original article
open access
published version
2022
,Acta Universitatis Carolinae. Geographica
,57
(1)
This article presents a detailed analysis of the fertility changes in Czechia since 1990 using the cohort approach and contributes to the overall understanding of the fertility postponement process. Because the timing of ...
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To screen or not to screen medical students for carriage of multidrug-resistant pathogens?
original article
open access
published version
2023
,Journal of Hospital Infection
,140
(October)
BACKGROUND: The aim of the study was to investigate the intestinal and nasal carriage of multidrug-resistant pathogens among medical students and its association with their lifestyle and demographic data. MATERIALS/METHODS: ...
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Metodika pro detekci Paenibacillus larvae a Melissococcus plutonius pomocí PCR v reálném čase
Methods for the detection of Paenibacillus larvae and Melissococcus plutonius using real-time PCR
certified methodology
open access
published version
2023
Metodika je určena laboratořím, které se zabývají diagnostikou nákaz včel. Detekce původců moru včelího plodu (Paenibacillus larvae) a hniloby včelího plodu (Melissococcus plutonius) je nezbytná pro prevenci šíření těchto ...
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Perception of safety and passage of time as factors influencing mode choice: The case of the Prague-Munich high-speed route
original article
open access
published version
2022
,Moravian Geographical Reports
,30
(1)
Behavioural factors of risk perception and time perception influencing the mode choice on the Prague-Munich route in relation to railway as a reference mode, are subject to evaluation in this article. Semi-structured ...
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Software infrastructure and data pipelines established for technical interoperability within a cross-border cooperation for the flora of the Bohemian Forest
original article
open access
published version
2022
,Biodiversity Data Journal
,10
(14.10.2022)
Background The timely and geographical resolutions, as well as the quantity and taxon concepts of records on the occurrence of plants near national borders is often ambiguous. This is due to the regional focus and different ...
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Household-level sanitation in Ethiopia and its influencing factors: a systematic review
original article
open access
published version
2022
,BMC Public Health
,22
(1)
Background Within the past two decades, Ethiopia has achieved one of the fastest reductions of open defecation worldwide. This change can be attributed to the implementation of a national sanitation strategy that focused ...
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Mining Heritage and Mining Landscape Krušnohoří/Erzgebirge as a Part of the UNESCO Heritage
original article
open access
published version
2022
,Land [online]
,11
(7)
The article deals with the perception and methods of management of the mining heritage and mining the landscapes from the perspective of individual stakeholders, entities and interest groups. The first part deals with the ...
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Mineralogical and Fluid Inclusion Evidence for Reworking of Au Mineralization by Ag-Sb-Base Metal-Rich Fluids from the Bytíz Deposit, Příbram Uranium and Base-Metal Ore District, Czech Republic
original article
open access
published version
2022
,Minerals
,12
(12)
This mineralogical and fluid inclusion study was conducted on an Au-bearing quartz-sulfide vein encountered in the deep parts of the Bytíz deposit in the Příbram uranium and base-metal district, Bohemian Massif, Czech ...
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Catalytic vs. uncatalyzed [2+2] photocycloadditions of quinones with alkynes
original article
open access
published version
2023
,Organic and Biomolecular Chemistry
,21
(30)
Photoreactions of quinones with alkynes under catalytic and non-catalytic conditions were studied. In contrast to recent reports, simple irradiation with blue light is sufficient to trigger [2 + 2] photocycloadditions, ...
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Transcripts of vaccinia virus postreplicative genes do not contain a 5' methylguanosine cap
abstract in e-form
open access
accepted version
2023
,The 28th Annual Meeting of the RNA Society
Vaccinia virus (VACV) is a prototypical poxvirus originally used for eradication of smallpox. Investigation into VACV mRNAs carried out almost half a century agosubstantially contributed to the fundamental discovery of the ...
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Loss of ADAR1 protein induces changes in small RNA landscape in hepatocytes
abstract in e-form
open access
accepted version
2023
,The 28th Annual Meeting of the RNA Society
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery and cellular antiviral response. It has been shown ...
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STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths
abstract in e-form
open access
accepted version
2023
,9th Prague-Weizmann Summer School in Drug Discovery & Development
Double-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines ...
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"Ouch!" or "Aah!": Are Vocalizations of 'Laugh', 'Neutral', 'Fear', 'Pain' or 'Pleasure' Reliably Rated?
original article
open access
published version
2023
,Human Ethology
,2023
(38)
Our research consisted of two studies focusing on the probability of humans being able to perceive the difference between valence of human vocalizations of high (pain, pleasure and fear) and low intensity (laugh and neutral ...
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Health inequalities in post-COVID-19 outcomes among adults aged 50+ in Europe: has COVID-19 exposed divide between postcommunist countries and Western Europe?
original article
open access
published version
2023
,Journal of Epidemiology and Community Health
,77
(9)
Background: COVID-19 affected people and countries disproportionately and continues to impact the health of people. The aim is to investigate protective health and socio-geographical factors for post-COVID-19 conditions ...
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Polysome profiling of oocytes, early development, and cell cycle in mammals
abstract in e-form
open access
submitted version
2023
,Neuvedeno
,2023
(Neuvedeno)
Polysome profiling has provided a gold-standard method to precisely assay functional genome readout at a given time point. The wide-spread utilisation of polysome profiling has nevertheless been historically hindered by ...
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The H3.3 histone variant and its chaperones in polyomaviral infection
abstract in conference proceedings
open access
submitted version
2023
,Praha
,WBW 2023 Book of Abstracts
Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of infection
