Faculty of Science: Poslední příspěvky
Zobrazují se záznamy 61-80 z 209
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PML nuclear bodies orchestrate antiviral response in HBV-infected hepatocytes
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
Promyelocytic leukaemia nuclear bodies (PML-NBs) play roles in various cellular functions and represent a key component of antiviral defense. In the case of hepatitis B virus (HBV), the antiviral ...
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MiRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV and melanoma cells
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
Interferon alfa (IFNα) is a pro-inflammatory cytokine with antiviral properties. Our project focuses on Toll-like receptors (TLR)7/9, which upon activation lead to a massive production of INFα.1Therefore, the process needs ...
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Role of the PML nuclear bodies and its associated histones chaperones in the remodeling of mouse polyomavirus minichromosomes
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of ...
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STING agonists activate multiple regulated cell death mechanisms in monocytes
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases, such as cancer or chronic ...
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Torque teno virus infection among psoriasis patients on biologic therapy
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
Torque teno virus (TTV) is a ubiquitous member of the healthy human virome with broad tissue tropism. TTV can induce chronic active infection without clinical manifestations. Although little is known about ...
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Creating a cell line suitable for investigation into the ADAR1 role in hepatitis C virus replication
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
Adenosine deaminases acting on RNA (ADAR) perform the adenosine to inosine (A-to-I) type of editing. Out of the three human ADAR proteins, ADAR1 is responsible for the majority of A-to-I editing of dsRNA outside the ...
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Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. ...
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Blood parasites (Trypanosoma, Leucocytozoon, Haemoproteus) in the Eurasian sparrowhawk (Accipiter nisus): diversity, incidence and persistence of infection at the individual level
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
Background :A high prevalence of parasites may result from life-long persistence of infection or from high reinfection rates. We have studied blood parasites in a breeding population of the accipitrid raptor, Eurasian ...
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Exploring the molecular mechanisms used by human BK polyomavirus to activate immune responses in "reservoir cells"
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
At present, the Polyomaviridae family contains 14 human polyomaviruses (PyVs), among the most important are Merkel cell polyomavirus (MCPyV), the etiological agent of 80% of Merkel cell carcinomas, JCPyV and BKPyV causing ...
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Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
původní článek
open access
vydavatelská verze
2023
,eLife
,12
(July)
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically ...
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HBV-induced microenvironment reduces pDC response to TLR7/9 stimulation
abstrakt v elektronické podobě
open access
vydavatelská verze
2023
Hepatitis B virus (HBV) is an infectious agent that causes acute hepatitis, but can also leadto chronic inflammation, and, consequently, to hepatocellular carcinoma. HBV is described as"stealth virus", since it avoids ...
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STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
abstrakt v elektronické podobě
open access
postprint
2023
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway plays a central role in recognition of the double-stranded DNA in cytoplasm, a sign of cell damage or infection. Upon activation, the pathway ...
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STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes
abstrakt v elektronické podobě
open access
postprint
2023
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
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Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease
původní článek
open access
vydavatelská verze
2023
,NPJ Parkinsons Disease
,9
(1)
Oxidative stress supposedly plays a role in the pathogenesis of Parkinson's disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative ...
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Understanding the Effect of Aspartate Hydroxylase Inhibition On T Cell-Mediated Immunity Using Single-Cell RNA Sequencing
abstrakt v elektronické podobě
open access
postprint
2023
,Neuvedeno
Overexpression of aspartate β-hydroxylase (ASPH) was found in 70-90% of solid tumors but is negligible in normal tissues. Increased ASPH contributes to tumor cell proliferation, migration, and invasion but can also affect ...
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Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
původní článek
open access
vydavatelská verze
2023
,Eurosurveillance
,28
(38)
Background: The sensitivity and specificity of selected antigen detection rapid diagnostic tests (AG-RDTs) for SARS-CoV-2 were determined in the unvaccinated population when the Delta variant was circulating. Viral loads, ...
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Human polyomaviruses in psoriasis patients on biologic treatment
abstrakt v elektronické podobě
open access
postprint
2023
,Neuveden
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
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Specific Immune Response Against SARS-CoV-2
abstrakt v elektronické podobě
open access
postprint
2023
,neuveden
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide. For effective treatment and introduction of appropriate antipandemic measures, it is necessary to understand the development ...
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Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
původní článek
open access
vydavatelská verze
2023
,European Journal of Medicinal Chemistry
,259
(November)
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell ...
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The crystal structure of bis(1H-pyrazole-carboxamidine-κN,N′)bis(nitrato-κO)-copper(II), C8H12CuN10O6
původní článek
omezený přístup
vydavatelská verze
2023
,Zeitschrift für Kristallographie - New Crystal Structures
,238
(2)
C8H12CuN10O6, triclinic, P1 (no. 2), a = 7.6063(5) Å, b = 9.3072(7) Å, c = 10.8485(8) Å, alpha = 81.370(2)°, beta = 75.503(2)°, gamma = 84.756(2)° V = 733.97(9) Å(3), Z = 2, R-gt(F) = 0.0515, wR(ref)(F-2) = 0.1194, T =120(2) K.
