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Group of cancer immunotherapy and molecular epidemiology of virus infections
(Praha, 2022)
The group is composed of the team of Laboratory of Molecular and Tumor Virology (headed by Ruth Tachezy) and Laboratory of Immunotherapy (headed by Michal Šmahel). While the research of the team led by Ruth Tachezy focuses ...
Role of population and test characteristics in antigen-based SARS-CoV-2 diagnosis, Czechia, August to November 2021
(2022)
Background: Analyses of diagnostic performance of SARS-CoV-2 antigen rapid diagnostic tests (AG-RDTs) based on long-term data, population subgroups and many AG-RDT types are scarce. Aim: We aimed to analyse sensitivity and ...
The microenvironment of HPV-associated and HPV-negative oropharyngeal tumors
(Řím, 2023)
Patients with HPV-associated oropharyngeal tumors have a survival advantage. They have better treatment response and less frequently develop recurrence. This recognition led to the inclusion of the indirect marker of an ...
Specific Immune Response Against SARS-CoV-2
(2023)
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide. For effective treatment and introduction of appropriate antipandemic measures, it is necessary to understand the development ...
Human polyomaviruses in psoriasis patients on biologic treatment
(2023)
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
(2022)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
(2023)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
Skin and oral virome in psoriasis patients on biologic therapy
(Praha, 2022)
The viral communities represent the most abundant microbiota population in humans. Viruses, together with other microbiota such as bacteria and fungi, form a dynamic ecosystem that influences the health of the host. The ...
Vývoj metodiky pro analýzu T-buněčné odpovědi proti viru SARS-CoV-2
Development of a procedure for the analysis of the T-cell response against SARS-CoV-2 virus
V roce 2020 způsobil koronavirus SARS-CoV-2 pandemii onemocnění covid-19. Pro detekci buněčné odpovědi vyvolané infekcí tímto virem byl vyvinut vysoce citlivý test ELISPOT detekující specifické lymfocyty T produkující ...
The Virome of Healthy Honey Bee Colonies: Ubiquitous Occurrence of Known and New Viruses in Bee Populations
(2022)
Honey bees are globally important pollinators threatened by many different pathogens, including viruses. We investigated the virome of honey bees collected at the end of the beekeeping season (August/September) in Czechia, ...