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Current research on A-to-I editing in the Laboratory of RNA biochemistry, Faculty of Science, Charles University
(Praha, 2022)
The paper summarizes the current status and planned research in the field of RNA editing at the Laboratory of RNA Biochemistry, Faculty of Science, Charles University
Novel 4-aminosalicylic acid analogues active against multidrug-resistant tuberculosis
(2022)
Spread of drug-resistant Mycobacterium tuberculosis (Mtb.), together with latent tuberculosis (TB), COVID-19 co-infection and increasing prevalence of non-tuberculous mycobacteria (NTM), is a serious threat for public ...
Inhibition of HBsAg secretion by a novel autophagy inducer
(Česká zemědělská univerzita v Praze, Praha, 2024)
Chronic hepatitis B (CHB) is a viral liver infection caused by hepatitis B virus (HBV), affecting over 300 million people world-wide. Untreated CHB can lead to liver cirrhosis and hepatocellular carcinoma, causing over ...
Hepatitis B virus hijacks host E2/E3 ubiquitin ligase, UBE2O, for viral nucleocapsid assembly and virion egress
(Praha, 2024)
Chronic hepatitis B (CHB) represents a serious liver disease that is caused by infection of Hepatitis Bvirus (HBV). CHB is associated with severe liver conditions ranging from fibrosis and cirrhosis tohepatocellular carcinoma ...
Effect of ADAR1 enzyme knockout on HCV replication
(Česká zemědělská univerzita, Praha, 2024)
The hepatitis C virus (HCV) is a member of the Flaviviridae family whose genome consists of a +RNAmolecule. It causes hepatitis C, a disease that affects tens of millions of people worldwide. Althoughthere is an effective ...
HBV-induced microenvironment reduces pDC response to TLR9 stimulation
(Nizozemsko, 2024)
Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ...
DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
(Nizozemsko, 2024)
Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ...
STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
(Nizozemsko, 2024)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ...
The differences in virome from distinct anatomical locations in psoriasis patients
(Česká zemědělská univerzita, Praha, 2024)
Psoriasis, a chronic autoimmune inflammatory disorder affecting 2-3% of the global population,exhibits a multifactorial aetiology with a significant genetic component and triggers such as trauma orinfection.
Specific Immunity to SARS-CoV-2 Infection
(Česká zemědělská univerzita, Praha, 2024)
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide.For effective treatment and introduction of appropriate anti-pandemic measures, it is necessary tounderstand the development ...