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STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
(2023)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway plays a central role in recognition of the double-stranded DNA in cytoplasm, a sign of cell damage or infection. Upon activation, the pathway ...
HBV-induced microenvironment reduces pDC response to TLR7/9 stimulation
(2023)
Hepatitis B virus (HBV) is an infectious agent that causes acute hepatitis, but can also leadto chronic inflammation, and, consequently, to hepatocellular carcinoma. HBV is described as"stealth virus", since it avoids ...
The H3.3 histone variant and its chaperones in polyomaviral infection
(Praha, 2023)
Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of infection
Role of TRAF6 adaptor in the immune responses to murine polyomavirus
(Tübingen, 2023)
Polyomaviruses are associated with many diseases due to their ability to persistently infect the host. Since 2008, twelve new human polyomaviruses have been discovered. Among the new species, Merkel cell polyomavirus (MCPyV) ...
Understanding the role of nuclear lamina during the murine polyomavirus infection using microscopy
(Montreal, 2023)
The nuclear lamina (NL) is a dense meshwork of intermediate filaments V, type A lamins (lamin A/C), type B lamins (lamin B1 and B2) and membrane associated proteins. NL is located closely adjacent to the nucleoplasmic side ...
Mouse PML protein isoforms and their role in Mouse Polyomavirus infection
(Praha, 2023)
Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, spherical, membrane-less structures composed of the main scaffold PML protein and a variety of stable or transient partner proteins. Apart from many endogenous ...
Can the type of oncogenic transformation by human papillomaviruses influence the choice of cancer immunotherapy?
(2023)
High-risk human papillomaviruses can induce malignant transformation of cells resulting in anogenital cancers, particularly cervical cancer (CC), and a proportion of head and neck squamous cell carcinomas ...
The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
(2023)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
Skin and oral virome in psoriasis patients on biologic therapy
(Praha, 2022)
The viral communities represent the most abundant microbiota population in humans. Viruses, together with other microbiota such as bacteria and fungi, form a dynamic ecosystem that influences the health of the host. The ...
Discovery of Small Molecule Activators of NRF1 Transcriptional Activity Preventing Protein Aggregation
(2023)
The intracellular accumulation of abnormal proteins exceeding their degradation can cause imbalance in proteostasis resulting in proteotoxic stress that leads to severe pathological stages. This state relates to proteasome ...