TET protein inhibitors: Potential and limitations

Autor
Venhauerová, Anna
Novotný, Petr
Babula, Petr
Datum vydání
2023Publikováno v
Biomedicine & PharmacotherapyRočník / Číslo vydání
166 (October)ISBN / ISSN
ISSN: 0753-3322ISBN / ISSN
eISSN: 1950-6007Metadata
Zobrazit celý záznamKolekce
Tato publikace má vydavatelskou verzi s DOI 10.1016/j.biopha.2023.115324
Abstrakt
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. Regulation of their activity by specific inhibitors could represent a promising therapeutic strategy. Therefore, this review describes various types of TET protein inhibitors in terms of their inhibitory mechanism and possible applicability. The potential and possible limitations of this approach are thoroughly discussed in the context of TET protein functionality in living systems. Furthermore, possible therapeutic strategies based on the inhibition of TET proteins are presented and evaluated, especially in the field of oncological diseases.
Klíčová slova
TET protein, Inhibitor, Cancer, Therapy, Mitochondria
Trvalý odkaz
https://hdl.handle.net/20.500.14178/2055Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ 4.0 International