Discovery of Small Molecule Activators of NRF1 Transcriptional Activity Preventing Protein Aggregation

Autor
Kůtová, Zuzana
Sedláček, Jindřich
Adámek, Michael
Majer, Pavel
Svobodová, Lucie
Kadlecová, Alena
Machara, Aleš
Bar IIan University
Datum vydání
2023Metadata
Zobrazit celý záznamKolekce
Abstrakt
The intracellular accumulation of abnormal proteins exceeding their degradation can cause imbalance in proteostasis resulting in proteotoxic stress that leads to severe pathological stages. This state relates to proteasome saturation/ insufficiency which requires upregulation of proteasome subunits. Nuclear Factor Erythroid 2-related factor 1 (NRF1) is a transcription factor (encoded by NFE2L1) which activates proteasome gene re-synthesis upon impairment of the proteasome function. Therefore, targeted activation of the NRF1 pathway could represent a new approach to delay the onset neurodegenerative diseases and other disorders with disturbed proteostasis.
Klíčová slova
proteostasis, NRF1, Protein
Trvalý odkaz
https://hdl.handle.net/20.500.14178/2101Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ 4.0 International