Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL

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Author
Lukeš, JuliusORCiD Profile - 0000-0003-1487-537XScopus Profile - 57203638156
Potůčková, EliškaScopus Profile - 56081081900
Alquezar Artieda, NatividadScopus Profile - 57217074171
Heřmanová, IvanaORCiD Profile - 0000-0002-3123-7540WoS Profile - I-4064-2015Scopus Profile - 36640020300
Kosanovic, Sladjana
Hložková, KateřinaScopus Profile - 57195679144
Alberich Jorda, MeritxellORCiD Profile - 0000-0002-8093-641XWoS Profile - G-3137-2014Scopus Profile - 6504493705
Zuna, JanScopus Profile - 6603899718
Trka, JanORCiD Profile - 0000-0002-9527-8608WoS Profile - Y-4820-2019Scopus Profile - 7004214671
Tennant, Daniel A
Stanulla, Martin
Žaliová, MarkétaORCiD Profile - 0000-0002-1639-7124Scopus Profile - 16481612200
Starková, JúliaORCiD Profile - 0000-0002-2269-5849Scopus Profile - 6507583180

Publication date
2023
Published in
HemaSphere
Volume / Issue
7 (9)
ISBN / ISSN
ISSN: 2572-9241
ISBN / ISSN
eISSN: 2572-9241
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Abstract
We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, themost frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter energy metabolism of leukemic cells, but surprisingly in a very distinct manner.
Keywords
Chimeric JAK2, Cellular Metabolism, BCR-ABL1-like Childhood ALL
Permanent link
https://hdl.handle.net/20.500.14178/2120
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WOS:001055544000004
SCOPUS:2-s2.0-85170417193
PUBMED:37637992
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