dc.contributor.author | Moťovská, Zuzana | |
dc.contributor.author | Hlinomaz, Ota | |
dc.contributor.author | Aschermann, Michael | |
dc.contributor.author | Jarkovský, Jiří | |
dc.contributor.author | Želízko, Michael | |
dc.contributor.author | Kala, Petr | |
dc.contributor.author | Groch, Ladislav | |
dc.contributor.author | Svoboda, Michal | |
dc.contributor.author | Hromádka, Milan | |
dc.contributor.author | Widimský, Petr | |
dc.date.accessioned | 2023-12-28T11:40:37Z | |
dc.date.available | 2023-12-28T11:40:37Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2146 | |
dc.description.abstract | Background: Sex- and gender-associated differences determine the disease response to treatment.Aim: The study aimed to explore the hypothesis that progress in the management of STE-myocardial infarction (STEMI) overcomes the worse outcome in women.Methods and results: We performed an analysis of three randomized trials enrolling patients treated with primary PCI more than 10 years apart. PRAGUE-1,-2 validated the preference of transport for primary PCI over on-site fibrinolysis. PRAGUE-18 enrollment was ongoing at the time of the functional network of 24/7PCI centers, and the intervention was supported by intensive antiplatelets. The proportion of patients with an initial Killip >= 3 was substantially higher in the more recent study (0.6 vs. 6.7%, p = 0.004). Median time from symptom onset to the door of the PCI center shortened from 3.8 to 3.0 h, p < 0.001. The proportion of women having total ischemic time <=3 h was higher in the PRAGUE-18 (OR [95% C.I.] 2.65 [2.03-3.47]). However, the percentage of patients with time-to-reperfusion >6 h was still significant (22.3 vs. 27.2% in PRAGUE-18). There was an increase in probability for an initial TIMI flow >0 in the later study (1.49 [1.0-2.23]), and also for an optimal procedural result (4.24 [2.12-8.49], p < 0.001). The risk of 30-day mortality decreased by 61% (0.39 [0.17-0.91], p = 0.029).Conclusion: The prognosis of women with MI treated with primary PCI improved substantially with 24/7 regional availability of mechanical reperfusion, performance-enhancing technical progress, and intensive adjuvant antithrombotic therapy. A major modifiable hindrance to achieving this benefit in a broad population of women is the timely diagnosis by health professional services. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.3389/fcvm.2022.953567 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-04-17T15:10:41Z | |
dc.subject.keyword | myocardial infarction | en |
dc.subject.keyword | primary PCI | en |
dc.subject.keyword | women | en |
dc.subject.keyword | outcome | en |
dc.subject.keyword | trends | en |
dc.subject.keyword | mortality | en |
dc.subject.keyword | therapy management | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/V-FN/V-VFN | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5104 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNP-05 | |
dc.date.embargoStartDate | 2024-04-17 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.3389/fcvm.2022.953567 | |
dc.identifier.utWos | 000913324400001 | |
dc.identifier.eidScopus | 2-s2.0-85146448325 | |
dc.identifier.obd | 621258 | |
dc.identifier.riv | RIV/00216208:11120/23:43925037 | |
dc.identifier.pubmed | 36684569 | |
dc.subject.rivPrimary | 30000::30200::30201 | |
dcterms.isPartOf.name | Frontiers in Cardiovascular Medicine | |
dcterms.isPartOf.issn | 2297-055X | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 9 | |
dcterms.isPartOf.journalIssue | January | |
uk.faculty.primaryId | 110 | |
uk.faculty.primaryName | 3. lékařská fakulta | cs |
uk.faculty.primaryName | Third Faculty of Medicine | en |
uk.faculty.secondaryId | 108 | |
uk.faculty.secondaryId | 111 | |
uk.faculty.secondaryId | 54 | |
uk.faculty.secondaryId | 53 | |
uk.faculty.secondaryName | 1. lékařská fakulta | cs |
uk.faculty.secondaryName | First Faculty of Medicine | en |
uk.faculty.secondaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.secondaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryName | Fakultní nemocnice Plzeň | cs |
uk.faculty.secondaryName | University Hospital in Pilsen | en |
uk.faculty.secondaryName | Všeobecná fakultní nemocnice v Praze | cs |
uk.faculty.secondaryName | Všeobecná fakultní nemocnice v Praze | en |
uk.department.primaryId | 110 | |
uk.department.primaryName | 3. lékařská fakulta | cs |
uk.department.primaryName | Third Faculty of Medicine | en |
uk.department.secondaryId | 1511 | |
uk.department.secondaryId | 634 | |
uk.department.secondaryId | 5000002755 | |
uk.department.secondaryId | 100030812918 | |
uk.department.secondaryId | 5000002598 | |
uk.department.secondaryName | II. interní klinika – klinika kardiologie a angiologie 1. LF UK a VFN | cs |
uk.department.secondaryName | 2nd Department of Medicine – Department of Cardiovascular Medicine | en |
uk.department.secondaryName | Kardiologická klinika 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of Cardiology 3FM CU and UHKV | en |
uk.department.secondaryName | Kardiologická klinika | cs |
uk.department.secondaryName | Department of Cardiology | en |
uk.department.secondaryName | Kardiologická klinika | cs |
uk.department.secondaryName | Department of Cardiology | en |
uk.department.secondaryName | II. interní klinika - klinika kardiologie a angiologie 1.LF a VFN | cs |
uk.department.secondaryName | II. interní klinika - klinika kardiologie a angiologie 1.LF a VFN | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials | en |