dc.contributor.author | Daniel, Petr | |
dc.contributor.author | Balušíková, Kamila | |
dc.contributor.author | Václavíková, Radka | |
dc.contributor.author | Šeborová, Karolína | |
dc.contributor.author | Ransdorfová, Šárka | |
dc.contributor.author | Valeriánová, Marie | |
dc.contributor.author | Wei, Longfei | |
dc.contributor.author | Jelínek, Michael | |
dc.contributor.author | Tlapáková, Tereza | |
dc.contributor.author | Fleischer, Thomas | |
dc.contributor.author | Kristensen, Vessela N. | |
dc.contributor.author | Souček, Pavel | |
dc.contributor.author | Ojima, Iwao | |
dc.contributor.author | Kovář, Jan | |
dc.date.accessioned | 2023-12-29T12:10:41Z | |
dc.date.available | 2023-12-29T12:10:41Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2162 | |
dc.description.abstract | A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant MCF-7 sublines (manifesting even higher TRIP6 expression). We found that TRIP6 transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines, TRIP6 co-amplification with the neighboring ABCB1 gene, as witnessed by fluorescence in situ hybridization (FISH), led to TRIP6 overexpression. Ultimately, we found high TRIP6 mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.3390/genes14020296 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-12-29T12:10:41Z | |
dc.subject.keyword | ABCB1 | en |
dc.subject.keyword | CpG methylation | en |
dc.subject.keyword | MCF-7 | en |
dc.subject.keyword | TRIP6 | en |
dc.subject.keyword | breast cancer | en |
dc.subject.keyword | cAMP response element | en |
dc.subject.keyword | gene amplification | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/GA0/GA/GA19-03063S | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5104 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM/LT/LTAUSA19032 | |
dc.date.embargoStartDate | 2023-12-29 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.3390/genes14020296 | |
dc.identifier.utWos | 000944841000001 | |
dc.identifier.eidScopus | 2-s2.0-85148869540 | |
dc.identifier.obd | 624738 | |
dc.identifier.pubmed | 36833223 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | Genes | |
dcterms.isPartOf.issn | 2073-4425 | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 14 | |
dcterms.isPartOf.journalIssue | 2 | |
uk.faculty.primaryId | 110 | |
uk.faculty.primaryName | 3. lékařská fakulta | cs |
uk.faculty.primaryName | Third Faculty of Medicine | en |
uk.faculty.secondaryId | 111 | |
uk.faculty.secondaryId | 115 | |
uk.faculty.secondaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.secondaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryName | Přírodovědecká fakulta | cs |
uk.faculty.secondaryName | Faculty of Science | en |
uk.department.primaryId | 110 | |
uk.department.primaryName | 3. lékařská fakulta | cs |
uk.department.primaryName | Third Faculty of Medicine | en |
uk.department.secondaryId | 100012968318 | |
uk.department.secondaryId | 576 | |
uk.department.secondaryId | 1035 | |
uk.department.secondaryName | Biomedicínské centrum | cs |
uk.department.secondaryName | Biomedical Center | en |
uk.department.secondaryName | Ústav biochemie, buněčné a molekulární biologie 3. LF UK | cs |
uk.department.secondaryName | Department of Biochemistry, Cell and Molecular Biology 3FM CU | en |
uk.department.secondaryName | Katedra buněčné biologie | cs |
uk.department.secondaryName | Department of Cell Biology | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines | en |