1. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 41-60 z 60
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Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration
původní článek
open access
vydavatelská verze
2022
,Biomedicine & Pharmacotherapy
,154
(October)
Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging ...
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COVID-19 Vaccination among Czech Dentists
původní článek
embargo
vydavatelská verze
2022
,Vaccines
,10
(3)
This work describes and evaluates vaccination against COVID-19 among members of the Czech Dental Chamber during the pre-booster vaccination phase. A cross-sectional online survey was conducted between 23 June and 4 September ...
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Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis
původní článek
open access
preprint
2022
,Journal of the National Cancer Institute
,114
(5)
BACKGROUND: Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type-2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. ...
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Development of ventricular trabeculae affects electrical conduction in the early endothermic heart
původní článek
open access
postprint
2024
,Developmental Dynamics
,253
(1)
Background: The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function ...
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AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
původní článek
open access
preprint
2022
,bioRxiv
,PREPRINT
This article is a preprint and has not been certified by peer review.
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Serum Bilirubin and Markers of Oxidative Stress and Inflammation in a Healthy Population and in Patients with Various Forms of Atherosclerosis
původní článek
open access
vydavatelská verze
2022
,Antioxidants
,11
(11)
Oxidative stress and inflammation contribute significantly to atherogenesis. We and others have demonstrated that mildly elevated serum bilirubin levels protect against coronary and peripheral atherosclerosis, most likely ...
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Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
původní článek
open access
vydavatelská verze
2022
,Metabolites [online]
,12
(12)
Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by biallelic mutations ...
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Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency
původní článek
open access
vydavatelská verze
2022
,Journal of Inherited Metabolic Disease
,45
(6)
Acid ceramidase catalyzes the degradation of ceramide into sphingosine and a free fatty acid. Acid ceramidase deficiency results in lipid accumulation in many tissues and leads to the development of Farber disease (FD). ...
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Restoration of functional network state towards more physiological condition as the correlate of clinical effects of pallidal deep brain stimulation in dystonia
původní článek
open access
vydavatelská verze
2022
,Brain Stimulation
,15
(5)
Background: Deep brain stimulation of the internal globus pallidus (GPi DBS) is an invasive therapeutic modality intended to retune abnormal central nervous system patterns and relieve the patient of dys-tonic or other ...
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Sex bias in multiple sclerosis and neuromyelitis optica spectrum disorders: How it influences clinical course, MRI parameters and prognosis
přehledový článek
open access
vydavatelská verze
2022
,Frontiers in Immunology
,13
(August)
This review is a condensed summary of representative articles addressing the sex/gender bias in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). The strong effects of sex on the incidence and ...
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Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis
původní článek
open access
vydavatelská verze
2022
,BMC Neurology
,22
(1)
Background: Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse ...
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Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells
původní článek
open access
vydavatelská verze
2022
,Biomedicine & Pharmacotherapy
,155
(November)
Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron chelator, are promising ...
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Engine shutdown: Migrastatic strategies and prevention of metastases
přehledový článek
embargo
vydavatelská verze
2023
,Trends in Cancer
,9
(4)
Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the ...
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Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators
původní článek
open access
vydavatelská verze
2022
,International Journal of Molecular Sciences
,23
(18)
Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated ...
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Autosomal dominant tubulointerstitial kidney disease: A review
přehledový článek
open access
vydavatelská verze
2022
,American Journal of Medical Genetics: Part C, Seminars in Medical Genetics
,190
(3)
The clinical characteristics of autosomal dominant tubulointerstitial kidney disease (ADTKD) include bland urinary sediment, slowly progressive chronic kidney disease (CKD) with many patients reaching end stage renal disease ...
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Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk
původní článek
open access
vydavatelská verze
2022
,Scientific Reports
,12
(1)
In the literature on the safety of ursodeoxycholic acid (UDCA) during breastfeeding, insufficient data has been reported to date. Thus, the aim of our study was to analyze bile acid (BA) concentrations in breast milk in a ...
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Otevřenost jako základ vědy a vědecké komunikace v 21. století
kapitola v kolektivní monografii
open access
vydavatelská verze
2016
,Brno
,Nakladatelství VUTIUM
,Otevřený přístup k vědeckým informacím: současný stav v České republice a ve světě
Kapitola je obecným úvodem do problematiky otevřenosti ve vědě a vědecké komunikaci (koncept open science).
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PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
původní článek
embargo
vydavatelská verze
2022
,Biomedicines
,10
(11)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunities
přehledový článek
open access
vydavatelská verze
2022
,Cells
,11
(22)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, ...
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Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial
původní článek
open access
vydavatelská verze
2023
,Nutrition & Diabetes [online]
,13
(1)
AIM: The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) ...
