Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 781-800 z 1817
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Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and ...
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Do kindergartens mitigate or exacerbate socioeconomic inequalities in language exposure? The case of home-based and kindergarten-based shared book reading activities in China
původní článek
open access
vydavatelská verze
2024
,Humanities & social sciences communications
,11
(1)
Shared book reading is a well-established practice for boosting children's language exposure and enhancing early development at home and in child care settings. The present study examined the socioeconomic gaps in home-based ...
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FosA3 emerging in clinical carbapenemase-producing C. freundii
původní článek
open access
vydavatelská verze
2024
,Frontiers in Cellular and Infection Microbiology
,14
(06 August 2024)
Fosfomycin (FOS) is an effective antibiotic against multidrug-resistant Enterobacterales, but its effectiveness is reducing. Little is known on the current prevalence of FosA enzymes in low-risk pathogens, such as Citrobacter ...
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Hidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A review
přehledový článek
open access
vydavatelská verze
2024
,Biomedicine & Pharmacotherapy
,180
(November)
Hydrazinecarboxamides (semicarbazides) are increasingly recognized as a versatile scaffold in developing potential antimicrobial agents. In addition to a brief overview of the synthetic methods to prepare them, this review ...
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ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Cancer is associated with alterations in key cellular pathways, including the aspartate ββ-hydroxylase (ASPH) pathway, an oncogene upregulated in various carcinomas that plays a crucial role in tumor progression and ...
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The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cancer: Pilot study
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study analyses the dynamics of human papillomavirus (HPV) cell cell-free DNA (cfDNA) levels ...
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Effect of the ADAR1 signalling pathway on HCV replication
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The hepatitis C virus (HCV) is a member of the Flaviviridae family, the genome of which consists of a +RNA molecule. It causes hepatitis C, which infects tens of millions of people worldwide. Although new direct direct-acting ...
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Unveiling viral diversity through wholevirome sequencing
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
In the dynamic landscape of viral metagenomics, our research focuses on whole-virome sequencing using the Novel enrichment technique of viromes protocol (NetoVir protocol, 1), which we have adapted to diverse starting ...
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Understanding the interplay between BK polyomavirus and celular restriction factors
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The most important human polyomavirus are the Merkel cell polyomavirus, the etiological agent of 80% of Merkel cell carcinoma, JCPyV that causes progressive multifocal leukoencephalopathy and BKPyV which causes nephropathy. ...
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miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. ...
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Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Polyomaviruses (PyVs) are small double-stranded DNA viruses that occur widely in nature. Among the 14 known human PyVs, three are particularly relevant: BK Polyomavirus (BKPyV), JC polyomavirus, and Merkel cell carcinoma ...
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Relationship between yeast virus like elements and poxviruses at the transcriptional level
abstrakt v elektronické podobě
open access
postprint
2024
,Czech Chemical Society Symposium Series
,22
(6)
Yeast cytoplasmic double-stranded DNA virus-like elements (VLEs, also known as linear plasmids) were found in a number of yeast species belonging to nine genera. The Kluyveromyces lactis pGKL1/2 plasmids, which serve as ...
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Interactome analysis of the mouse polyomavirus large T antigen
abstrakt v elektronické podobě
open access
postprint
2024
,Czech Chemical Society Symposium Series
,22
(6)
Polyomaviruses are small nonenveloped viruses that replicate in the nucleus of the host cell. The mouse polyomavirus (MPyV) large T antigen (LT) is the multifunctional protein expressed in the early phase of the viral ...
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Small-molecule activators of NRF1 transcriptional activity prevent protein aggregaton
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Intracellular protein aggregation causes proteotoxic stress, underlying highly debilitating neurodegenerative disorders in parallel with decreased proteasome activity.Nevertheless, under such stress conditions, the expression ...
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Novel autophagy inducer inhibits hepatitis B virus S antigen secretion
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
Chronic hepatitis B (CHB), a liver infection caused by the hepatitis B virus (HBV), affects more than 300 million people worldwide. If left untreated, CHB can progress to liver cirrhosis and hepatocellular carcinoma, ...
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Parental views on their children’s smartphone use during personal and relational activities
původní článek
open access
vydavatelská verze
2024
,Public Library of Science
,PLoS One
,19
(8)
Given the negative outcomes associated with smartphone use during personal and relational activities (SUPRA), parents strive to regulate its use among their children. However, media parenting recommendations lack knowledge ...
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
původní článek
open access
vydavatelská verze
2024
,Cell Press, Elsevier, Inc.
,iScience
,27
(10)
DDI2 is an aspartic protease that cleaves polyubiquitinated substrates. Upon proteotoxic stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1), crucial for maintaining proteostasis in mammalian cells, enabling ...
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Positive Effect of a Cooling Cap on Functional Performance in Thermosensitive People with Multiple Sclerosis: A Randomized Controlled Trial
původní článek
open access
vydavatelská verze
2024
,Munksgaard
,Acta Neurologica Scandinavica
,2024
(April)
Background. Up to 80% of people with MS experience worsening of their condition upon an increase in body temperature. Therefore, various options of cooling are being evaluated to help improve physical performance in people ...
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School choice and parenting strategies among Czech middle‐class parents : Implications for social segregation in public schools
původní článek
open access
vydavatelská verze
2024
,Sociology Compass
,e13248
(23.7.2024)
Research examining middle-class parents' school choices often overlooks parents in post-socialist nations, where social reproduction may occur differently than in Western urban contexts. To bridge this gap, our study ...
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Why do teachers leave schools? Evidence from lower secondary schools in the Czech Republic
původní článek
open access
vydavatelská verze
2024
,International Journal of Educational Management
,neuveden
(18.2.2024)
Purpose - This study aims to supplement the international knowledge on factors determining retention in theteaching profession with findings from the Czech Republic. The study aims to answer the question of whatfactors on ...
