Repozitář publikační činnosti UK: Recent submissions
Now showing items 101-120 of 1883
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The role of myotubularin-related lipid phosphatases in cancer pathogenesis
summarizing article
open access
published version
2026
,Academic Press
,Experimental and Molecular Pathology
,145
(January)
Myotubularin-related proteins (MTMRs) comprise a family of lipid phosphatases using phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate as their substrate. Several members have a well-established ...
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Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis
original article
open access
published version
2025
,Harcourt
,Placenta
,172
(December)
Objective: Adenosine and other nucleosides are essential regulators of cellular processes, but their specific roles in trophoblast growth and regulation remain incompletely defined. This study investigated the effects of ...
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Structure-Activity Relationships of Novel Pyrimidine Derivatives as potential antimycobacterial Agents
abstract in conference proceedings
open access
published version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death from a single infectious agent, exerting severe health and economic burdens, particularly in Sub-Saharan Africa and South-East ...
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Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases
abstract in conference proceedings
open access
published version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...
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Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit
original article
open access
published version
2025
,Elsevier
,Biomedicine & Pharmacotherapy
,192
(November)
Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse ...
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Integrating Long-Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia
original article
open access
published version
2026
,John Wiley & Sons
,Movement Disorders
,41
(1)
Background: Although many individuals with dystonia present with features indicative of single-gene etiologies, obtaining definitive genetic diagnoses can be challenging. Objective: We assessed the value of nanopore-based ...
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Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia
original article
open access
published version
2025
,Sleep Medicine
,129
(May)
Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study ...
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Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease
article in reviewed proceedings
open access
published version
2025
,EDP Sciences
,Bio Web of Conferences
,195
Parkinson’s disease (PD) and isolated REM sleep behaviour disorder (iRBD) are neurodegenerative conditions associated with alterations in the striatum, a subcortical structure essential for motor and cognitive functions. ...
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Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in de novo Parkinson's disease
original article
open access
published version
2025
,IOS Press
,Journal of Parkinson's Disease
,15
(8)
Background: Given the increasing global prevalence of Parkinson's disease (PD) and its complex etiopathogenesis, understanding the role of environmental factors is crucial. Prior investigations suggested a potential link ...
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De Novo Variants in PPFIA2 in Individuals With Neurodevelopmental Disorders
casuistics
open access
published version
2026
,Wiley-Liss
,American Journal of Medical Genetics: Part A
,200
(2)
Liprin-alpha 2, encoded by PPFIA2, belongs to the family of Liprin-alpha proteins which constitute major synaptic scaffolds participating in the assembly and maturation of synapses. Heterozygous de novo variants in PPFIA2 ...
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Novel structure motif for the selective inhibition of TET1 protein based on perimidines
original article
open access
published version
2026
,Elsevier B.V.
,Journal of Molecular Structure
,1349
(January)
The targeting of epigenetic factors, particularly TET proteins (ten-eleven translocation methylcytosine dioxygenases), has emerged as a significant focus in medicinal and biological research. Recent findings indicate that ...
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Low-Intensity Constant Light During Early Postnatal Development Induces Sex-Specific Anxiety-Like Behaviour and Region- and Sex-Specific Changes in Circadian Gene Expression and RNA Editing
original article
open access
accepted version
2026
,Kluwer
,Cellular and Molecular Neurobiology
,46
(1)
Early-life exposure to light at night can disrupt the maturation of the circadian system and lead to long-lasting behavioural and molecular alterations. We exposed rat pups to constant light (LL; 16 lx) from birth (P0) to ...
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Role a postavení interkulturních pracovníků v poskytování zdravotní péče uprchlíkům a migrantům v Česku
The role and position of intercultural workers in the provision of health care to refugees and migrants in the Czech Republic
original article
open access
published version
2025
,Časopis lékařů českých
,164
(1)
Interkulturní pracovníci (též interkulturní mediátoři, komunitní tlumočníci) hrají klíčovou roli v překonávání jazykových a kulturních bariér mezi migranty a zdravotnickými systémy hostitelských zemí. Světová zdravotnická ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
original article
open access
published version
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Monotheism of the Divine Names and Attributes as a Defining Criterion of Salafism
original article
open access
published version
2025
,Brill
,Die Welt des Islams
,Neuveden
(2025)
This study examines how Saudi Salafism, as a modern ideological construct, hasgradually linked the theological teachings about the monotheism of the Divine namesand attributes (tawḥīd al-asmāʾ wa-l-ṣifāt) of the Ḥanbalī ...
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Aktuální otázky práva autorského a práv průmyslových : Autorskoprávní aspekty generativní umělé inteligence - konference k poctě prof. JUDr. Karla Knapa, CSc
collection of papers
open access
published version
2025
,Praha
,Univerzita Karlova, Právnická fakulta
Autorské právo se v posledních třiceti letech muselo potýkat s řadou změn, které byly ve valné většině zapříčiněny technologickým rozvojem. Hromadné rozšíření inter- netu otřáslo tradičními obchodními schématy kreativních ...
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Kárná rozhodnutí České advokátní komory a jejich možný význam pro daňové poradce
Disciplinary Decisions of the Czech Bar Association and Their Potential Relevance for Tax Advisors
original article
open access
published version
2025
,Komora daňových poradců České republiky
,Bulletin Komory daňových poradců České republiky
,Neuveden
(4)
Článek nabízí daňovým poradcům vhled do kárné praxe České advokátní komory a ukazuje, v jakých ohledech může být tato praxe inspirativní pro výkon profese daňového poradenství, přestože právní regulace profesí se liší a ...
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Doktrína, nebo empirie? Metodologie,etika a financování českého právního výzkumu
Doctrine or Empiricism? Methodology, Ethics, and Funding of Czech Legal Research
original article
open access
published version
2025
,Právnická fakulta Univerzity Karlovy
,Jurisprudence
,2025
(4-5)
V příspěvku pojednáváme o aktuálních problematických aspektech českého právního výzkumu. Ty spatřujeme v 1) neujasněnosti, které činnosti považovat za právní výzkum, jak je označovat, kategorizovat, jaké základní standardy ...
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Beyond Deterrence: Experimental Study of Factors Influencing Perceived Legitimacy and Compliance With Mandatory Vaccination
original article
open access
published version
2025
,Regulation and Governance
,2025
(May)
For the law to function effectively in society, it must not only be enforced but also promote compliance, particularly in emotionally charged, polarized, or uncertain situations. This study explores the impact of legal ...
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Střety zájmů při ochraně biodiverzity a klimatu a jejich řešení z pohledu práva = Conflicts of Interest in Biodiversity and Climate Protection and their Resolution from a Legal Perspective
Conflicts of Interest in Biodiversity and Climate Protection and their Resolution from a Legal Perspective
collection of papers
open access
published version
2025
,Praha
,Univerzita Karlova, Právnická fakulta
Změna klimatu a úbytek biodiverzity představují v současné době nejzávažnější glo- bální problémy životního prostředí. Podle modelu tzv. planetárních mezí či limitů Země,1 který vymezuje devět oblastí, devět limitů Země, ...
