Now showing items 101-120 of 1843

    • Rivaroxaban, in combination with low-dose aspirin, is associated with a reduction in proinflammatory and prothrombotic circulating vesicle signatures in patients with cardiovascular disease 

      original article

      open access

      published version

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      Weiss, Luisa

      ;

      O'Doherty, Aideen

      ;

      Uhrig, Wido

      ;

      Szklanna, Paulina B.

      ;

      Hong-Minh, Molly

      ;

      Wynne, Kieran

      ;

      Blanco, Alfonso

      ;

      Živný, Jan

      ;

      Passos, Valeria Lima

      ;

      Kevane, Barry

      ;

      Murphy, Sean

      ;

      Ainle, Fionnuala Ni

      ;

      O'Donnell, Martin

      ;

      Maguire, Patricia B.

      2025

      ,

      Journal of Thrombosis and Haemostasis

      ,

      23

      (2)

      Background: Despite secondary prevention with aspirin, patients with stable cardiovascular disease (CVD) remain at elevated long-term risk of major adverse cardiovascular events. The Cardiovascular Outcomes in People Using ...

    • Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic 

      original article

      open access

      published version

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      Chudějová, Kateřina

      ;

      Sourenian-Samuelian, Tsolaire

      ;

      Finianos, Marc

      ;

      Šrámková, Anna

      ;

      Papagiannitsis, Costas C

      ;

      Hrabák, Jaroslav

      ;

      Bitar, Ibrahim

      2026

      ,

      ASM Press

      ,

      Microbiology Spectrum

      ,

      14

      (1)

      A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...

    • Health and care workforce preparedness in response to the influx of Ukrainian refugees: a qualitative study from the Czech Republic 

      original article

      open access

      published version

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      Kotherová, Zuzana

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      Dobiášová, Karolína

      ;

      Kopsa Těšinová, Jolana

      ;

      Tulupova, Elena

      2026

      ,

      Elsevier

      ,

      Health Policy

      ,

      163

      (January)

      Background: Health and care workforces across Europe face overlapping crises that test their resilience and governance capacities. In the Czech Republic, the COVID-19 pandemic was swiftly followed by a major influx of ...

    • Central European Presidents, Prime Ministers, and War. Executive Dualism and Foreign Policy in International Conflicts 

      monograph

      open access

      published version

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      Kubát, Michal

      ;

      Kopeček, Lubomír

      ;

      Hloušek, Vít

      ;

      Kysela, Jan

      2026

      ,

      Cham

      ,

      Palgrave Macmillan

      This book offers an in-depth examination of how presidents, prime ministers, and their cabinets navigate relationships and make decisions during international crises. The authors focus particularly on war and its effect ...

    • VAST INCREASE IN SECOND PRIMARY LUNG CANCERS IN SWEDEN 

      original article

      open access

      submitted version

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      Zitrický, František

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      Sundquist, Kristina

      ;

      Sundquist, Jan

      ;

      Försti, Asta

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      Hemminki, Akseli

      ;

      Kaaks, Rudolf

      ;

      Hemminki, Kari Jussi

      2025

      Background: We describe the occurrence of second primary lung cancers (SPLCs) and their determinant in Sweden.Methods: Nation-wide cancer registry from years 1961 to 2021 identified a total of 853 SPLCs.Results: The incidence ...

    • Spatial Patterns and Prognostic Relevance of CD1a Immature and CD208 Mature Dendritic Cells in Colorectal Cancer From Tumour-adjacent Mucosa to Liver 

      original article

      open access

      submitted version

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      Pavlov, Sergii

      ;

      Ali, Esraa

      ;

      Ye, Wenjing

      ;

      Červenková, Lenka

      ;

      Ambrożkiewicz, Filip

      ;

      Vyčítal, Ondřej

      ;

      Daum, Ondřej

      ;

      Liška, Václav

      ;

      Hemminki, Kari Jussi

      ;

      Trailin, Andriy

      2026

      ,

      Springer

      ,

      Cancer Immunology, Immunotherapy

      ,

      75

      (1)

      Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...

    • Voyvodovo identities at the crossroads of interpretative paradigms. Symbolic interpretation of Voyvodovo religiosity 

      original article

      open access

      published version

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      Jakoubková Budilová, Lenka

      ;

      Jakoubek, Marek

      2025

      ,

      Университетско издателство "Св. Климент Охридски"

      ,

      Godišnik na Sofijskiâ universitet Sv. Kliment Ohridski. Istoričeski fakultet

      ,

      108

      (1)

      The article is focused on Voyvodovo, a village in the Danube region of northwestern Bulgaria. The authors discuss collective identities of Voyvodovans, before theirresettlement to Czechoslovakia after WWII. Founded by the ...

    • Healing or hurting?: Interpretations of possession as a disease in the second half of the 19th and early 20th century press 

      original article

      open access

      published version

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      Ondreička, Peter

      2022

      ,

      Axis Mundi

      ,

      17

      (2)

      This study focuses on articles published in the second half of the 19th century and early 20th century inwhich possessionwas portrayed as a disease, be it mental or physical.At the beginning, we will briefly show how ...

    • Genomic islands and molecular mechanisms relating to drug-resistance in Clostridioides (Clostridium) difficile PCR ribotype 176 

      original article

      open access

      published version

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      Krůtová, Marcela

      ;

      Kovarovic, Vojtech

      ;

      Brajerová, Marie

      ;

      Demay, Fanny

      ;

      Zíková, Jaroslava

      ;

      Prasad, Suhanya Veronica

      ;

      Soltesova, Anna

      ;

      Novakova, Elena

      ;

      Pituch, Hanna

      ;

      Kuijper, Ed

      ;

      Smits Wiep, Klaas

      ;

      Balikova Novotna, Gabriela

      2025

      ,

      Springer Nature

      ,

      Emerging Microbes & Infections

      ,

      14

      (1)

      OBJECTIVES: To analyse characteristics of Clostridioides difficile PCR ribotype 176 clinical isolates from Poland, the Czech Republic and Slovakia with regard to the differences in its epidemiology. METHODS: Antimicrobial ...

    • ESBL-producing and colistin-resistant Enterobacterales among Czech international travellers: genomic relatedness to community and environmental isolates 

      original article

      open access

      published version

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      Prasad, Suhanya Veronica

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      Dratvová, Barbora

      ;

      Antušková, Milena

      ;

      Brajerová, Marie

      ;

      Nycova, Elka

      ;

      Adamová, Eva

      ;

      Trojánek, Milan

      ;

      Tkadlec, Jan

      ;

      Dřevínek, Pavel

      ;

      Krůtová, Marcela

      2025

      ,

      Elsevier

      ,

      Travel Medicine and Infectious Disease

      ,

      68

      (November–December)

      BACKGROUND: While antimicrobial resistance in Enterobacterales is closely monitored in healthcare settings, much less is known about the circulation of these bacteria in the community, particularly in high-risk groups such ...

    • Minimal residual disease assessment following CD19-targeted therapy in B-cell precursor acute lymphoblastic leukemia using standardized 12-color flow cytometry: A EuroFlow study 

      original article

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      published version

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      Verbeek, Martijn W C

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      Reiterová, Michaela

      ;

      Laqua, Anna

      ;

      Rodríguez, Beatriz Soriano

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      Sedek, Lukasz

      ;

      Buracchi, Chiara

      ;

      Buysse, Malicorne

      ;

      Oliveira, Elen

      ;

      Engelmann, Robby

      ;

      Desterro, Joana

      ;

      De Jong, Anja X

      ;

      Boettcher, Sebastian

      ;

      Jugooa, Romana

      ;

      Barrena, Susana

      ;

      Kohlscheen, Saskia

      ;

      Nierkens, Stefan

      ;

      Rodriques, Joana G

      ;

      Hofmans, Mattias

      ;

      Gaipa, Giuseppe

      ;

      Sobral de Costa, Elaine

      ;

      Mejstříková, Ester

      ;

      Szczepanski, Tomasz

      ;

      Brüggemann, Monika

      ;

      van Dongen, Jacques J M

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      Orfao, Alberto

      ;

      van der Velden, Vincent H J

      2025

      ,

      Wolters Kluwer Health, Inc.

      ,

      HemaSphere

      ,

      9

      (4)

      Detection of minimal/measurable residual disease (MRD) is a critical prognostic marker in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The EuroFlow Consortium previously developed an 8-color flow cytometric MRD ...

    • Molecular Landscape of Pediatric Low-Grade Gliomas: Insights From RNA-NGS and Bioinformatic Analysis 

      original article

      open access

      published version

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      Brož, Petr

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      Strnadová, Martina

      ;

      Olejníková, Denisa

      ;

      Kotiš, Johana

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      Pospíšilíková, Tereza

      ;

      Mišove, Adéla

      ;

      Koblížek, Miroslav

      ;

      Zámečník, Josef

      ;

      Zápotocký, Michal

      ;

      Sumerauer, David

      ;

      Vícha, Aleš

      ;

      Kynčl, Martin

      ;

      Libý, Petr

      ;

      Beneš, Vladimír

      ;

      Krsková, Lenka

      2025

      ,

      Wiley-Liss, Inc.

      ,

      Genes, Chromosomes & Cancer

      ,

      64

      (10)

      Pediatric low-grade gliomas (pLGG) are the most common group of childhood brain tumors. Genetic alterations in the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway are the molecular drivers in the vast majority of ...

    • Flow-cytometric MRD detection in pediatric T-ALL: a multicenter AIEOP-BFM consensus-based guided standardized approach 

      original article

      open access

      published version

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      Reiterová, Michaela

      ;

      Kohlscheen, Saskia

      ;

      Maglia, Oscar

      ;

      Sala, Simona

      ;

      Schumich, Angela

      ;

      Maurer-Granofszky, Margarita

      ;

      Faggin, Giovanni

      ;

      Scarparo, Pamela

      ;

      Varotto, Elena

      ;

      Šestáková, Zuzana

      ;

      Švec, Peter

      ;

      Feuerstein, Tamar

      ;

      Vernitsky, Helly

      ;

      Kužílková, Daniela

      ;

      Hrušák, Ondřej

      ;

      Buldini, Barbara

      ;

      Dworzak, Michael

      ;

      Brüggemann, Monika

      ;

      Gaipa, Giuseppe

      ;

      Kalina, Tomáš

      2025

      ,

      de Gruyter

      ,

      Clinical Chemistry and Laboratory Medicine

      ,

      63

      (7)

      OBJECTIVES: Risk-based stratification approaches using measurable residual disease (MRD) successfully help to identify T-acute lymphoblastic leukemia (T-ALL) patients at risk of relapse, whose treatment outcomes are very ...

    • NGS-MRD negativity in post-HSCT ALL spares unnecessary therapeutic interventions triggered by borderline qPCR results without an increase in relapse risk 

      original article

      open access

      published version

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      Šeferna, Kryštof

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      Svatoň, Michael

      ;

      Rennerová, Andrea

      ;

      Skotnicová, Aneta

      ;

      Řezníčková, Leona

      ;

      Valová, Taťána

      ;

      Sedláček, Petr

      ;

      Říha, Petr

      ;

      Formánková, Renata

      ;

      Keslová, Petra

      ;

      Šrámková, Lucie

      ;

      Starý, Jan

      ;

      Zuna, Jan

      ;

      Kolenova, Alexandra

      ;

      Šálek, Cyril

      ;

      Trka, Jan

      ;

      Froňková, Eva

      2025

      ,

      HemaSphere

      ,

      9

      (4)

      Monitoring of minimal residual disease (MRD) after hematopoietic stem cell transplantation (HSCT) in patients with acute lymphoblastic leukemia (ALL) is vital for timely therapeutic intervention planning. However, interpreting ...

    • Zpráva z konference Daňové právo 2025: Daň z přidané hodnoty 

      other article

      open access

      published version

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      Málek, Ondřej

      2025

      ,

      Komora daňových poradců České republiky

      ,

      e-Bulletin Komory daňových poradců České republiky

      ,

      Neuveden

      (12)

      Začátkem října se na půdě Právnické fakulty Univerzity Karlovy konala konference Daňové právo 2025: Daň z přidané hodnoty. Událost přilákala bezmála 130 účastníků z řad poradců, advokátů, pracovníků Finanční správy i ...

    • Party takeovers as alternative routes into politics: evidence from Slovakia 

      original article

      open access

      published version

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      Malý, Michal

      ;

      Žiljak, Filip

      2025

      ,

      Routledge, Taylor & Francis

      ,

      European Politics and Society

      ,

      Neuveden

      (1.12.2025)

      This article examines external party takeovers, the acquisition and repurposing of existing parties by outside actors, as an alternative route into electoral competition. While research on party formation has focused on ...

    • Science advice at the top: a global overview of chief science advisor model in governance 

      original article

      open access

      published version

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      Pštross, Karolína

      ;

      Firestein, Stuart

      ;

      Almeida, Paulo

      ;

      Pasternak, Natalia

      2025

      ,

      Beech Tree Publishing

      ,

      Science and Public Policy

      ,

      2025

      (17. 11. 2025)

      Science advice plays a key role in policymaking, with governments adopting various models to integrate expertise into decision-making. This study provides a preliminary overview of the Chief Science Advisor (CSA) model, ...

    • N-Aryl-N-Lactosylamides as Potent and Highly Selective Inhibitors of Galectin-3 with Antifibrotic Activity 

      original article

      open access

      published version

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      Zýka, Jakub

      ;

      Kozák, Jaroslav

      ;

      Vaneková, Lenka

      ;

      Pimková Polidarová, Markéta

      ;

      Prouza, Vít

      ;

      Habanová, Nina

      ;

      Strmeň, Timotej

      ;

      Zavřel, Martin

      ;

      Pachl, Petr

      ;

      Choutka, Jan

      ;

      Grantz Šašková, Klára

      ;

      Brázdová, Andrea

      ;

      Parkan, Kamil

      ;

      Pohl, Radek

      2025

      ,

      ACS Publications

      ,

      Journal of Medicinal Chemistry

      ,

      68

      (22)

      Galectin-3 (Gal-3) is a galactose-binding lectin involved in pathologies such as inflammation, fibrosis, heart disease, and tumor progression. Here, we report N-aryl-N-(thio)lactosylamides as a novel class of Gal-3 inhibitors. ...

    • Herbicides vs herbicidal ionic liquids - does the herbicide application form affect the properties of active components? 

      original article

      open access

      published version

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      Mullerova, Tereza

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      Wilms, Wiktoria Malgorzata

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      Niemczak, Michal

      ;

      Syguda, Anna

      ;

      Rzemieniecki, Tomasz

      ;

      Wozniak-Karczewska, Marta

      ;

      Semerád, Jaroslav

      ;

      Škrob, Zdena

      ;

      Frouz, Jan

      ;

      Chrzanowski, Lukasz

      ;

      Cajthaml, Tomáš

      2025

      ,

      ELSEVIER

      ,

      Journal of Hazardous Materials

      ,

      19

      (August 2025)

      Despite extensive research on ionic liquids (ILs), their environmental fate remains poorly understood. Cation toxicity is generally considered the primary determinant of the final properties of the ILs. However, the relevance ...

    • Hodnota sporu 

      Value of the Dispute

      chapter in a collective monograph

      open access

      published version

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      Sedláček, Miroslav

      2025

      ,

      Praha

      ,

      Wolters Kluwer ČR

      ,

      Vedení civilního soudního řízení – mikro a makro řízení civilních soudních sporů o peněžitá plnění. Základní východiska

      Kapitola se zabývá institutem hodnoty sporu jako klíčovým parametrem civilního procesu. Ukazuje její význam nejen z hlediska case managementu, kde určuje přiměřenost procesních postupů, ale také v rovině právní při posuzování ...