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STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms
(Česká společnost chemická, Praha, 2023)
The immune cells respond to the double-stranded DNA (dsDNA) or cyclic dinucleotide (CDN)-mediated stimulation of the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway by secretion of type I ...
Influence of the microenvironment of hepatitis B virus-infected hepatocytes on innate immunity's mechanisms
(Česká společnost chemická, Praha, 2023)
HBV virus is an infectious agent that replicates in the hepatocytes and causes an acute form of hepatitis, but it can also lead to a chronical inflammation, and consequently, to a hepatocellular carcinoma. HBV virus is ...
Education as the Tool of the Involvement in Physical Activity
Vzdělávání jako nástroj zapojení do pohybové aktivity
The paper deals with the issue of an education and its relationship with healthy lifestyle, namely with sport and other physical activity among Czech adult population.The research question was if people with higher education ...
Role of E2/E3 ubiquitin ligase, UBE2O, in Hepatitis B virus replication
(2023)
Chronic hepatitis represents a life-long liver disease caused by infection of Hepatitis B virus (HBV) and affecting more than 250 million people worldwide. Since HBV replication is completely dependent upon host cell protein ...
Creating a cell line suitable for investigation into the ADAR1 role in hepatitis C virus replication
(2023)
Adenosine deaminases acting on RNA (ADAR) perform the adenosine to inosine (A-to-I) type of editing. Out of the three human ADAR proteins, ADAR1 is responsible for the majority of A-to-I editing of dsRNA outside the ...
Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
(2023)
The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. ...
MiRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV and melanoma cells
(2023)
Interferon alfa (IFNα) is a pro-inflammatory cytokine with antiviral properties. Our project focuses on Toll-like receptors (TLR)7/9, which upon activation lead to a massive production of INFα.1Therefore, the process needs ...
PML nuclear bodies orchestrate antiviral response in HBV-infected hepatocytes
(2023)
Promyelocytic leukaemia nuclear bodies (PML-NBs) play roles in various cellular functions and represent a key component of antiviral defense. In the case of hepatitis B virus (HBV), the antiviral ...
Role of the PML nuclear bodies and its associated histones chaperones in the remodeling of mouse polyomavirus minichromosomes
(2023)
Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of ...
Exploring the molecular mechanisms used by human BK polyomavirus to activate immune responses in "reservoir cells"
(2023)
At present, the Polyomaviridae family contains 14 human polyomaviruses (PyVs), among the most important are Merkel cell polyomavirus (MCPyV), the etiological agent of 80% of Merkel cell carcinomas, JCPyV and BKPyV causing ...