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STING agonist-induced cytokine production with anti-HBV activity is accompanied by immunogenic cell death of monocytes
(2023)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathwayrecognizes cytosolic double-stranded DNA (dsDNA), a sign of viral infection or cell damage.Activation of the pathway stimulates immune cells ...
HBV-induced microenvironment reduces pDC response to TLR7/9 stimulation
(2023)
Hepatitis B virus (HBV) is an infectious agent that causes acute hepatitis, but can also leadto chronic inflammation, and, consequently, to hepatocellular carcinoma. HBV is described as"stealth virus", since it avoids ...
Role of TRAF6 adaptor in the immune responses to murine polyomavirus
(Tübingen, 2023)
Polyomaviruses are associated with many diseases due to their ability to persistently infect the host. Since 2008, twelve new human polyomaviruses have been discovered. Among the new species, Merkel cell polyomavirus (MCPyV) ...
Influence of the microenvironment of hepatitis B virus-infected hepatocytes on innate immunity's mechanisms
(Česká společnost chemická, Praha, 2023)
HBV virus is an infectious agent that replicates in the hepatocytes and causes an acute form of hepatitis, but it can also lead to a chronical inflammation, and consequently, to a hepatocellular carcinoma. HBV virus is ...
Role of E2/E3 ubiquitin ligase, UBE2O, in Hepatitis B virus replication
(2023)
Chronic hepatitis represents a life-long liver disease caused by infection of Hepatitis B virus (HBV) and affecting more than 250 million people worldwide. Since HBV replication is completely dependent upon host cell protein ...
MiRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV and melanoma cells
(2023)
Interferon alfa (IFNα) is a pro-inflammatory cytokine with antiviral properties. Our project focuses on Toll-like receptors (TLR)7/9, which upon activation lead to a massive production of INFα.1Therefore, the process needs ...
PML nuclear bodies orchestrate antiviral response in HBV-infected hepatocytes
(2023)
Promyelocytic leukaemia nuclear bodies (PML-NBs) play roles in various cellular functions and represent a key component of antiviral defense. In the case of hepatitis B virus (HBV), the antiviral ...
Inhibition of HBsAg secretion by a novel autophagy inducer
(Česká zemědělská univerzita v Praze, Praha, 2024)
Chronic hepatitis B (CHB) is a viral liver infection caused by hepatitis B virus (HBV), affecting over 300 million people world-wide. Untreated CHB can lead to liver cirrhosis and hepatocellular carcinoma, causing over ...
Hepatitis B virus hijacks host E2/E3 ubiquitin ligase, UBE2O, for viral nucleocapsid assembly and virion egress
(Praha, 2024)
Chronic hepatitis B (CHB) represents a serious liver disease that is caused by infection of Hepatitis Bvirus (HBV). CHB is associated with severe liver conditions ranging from fibrosis and cirrhosis tohepatocellular carcinoma ...
HBV-induced microenvironment reduces pDC response to TLR9 stimulation
(Nizozemsko, 2024)
Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ...