dc.contributor.author | Blažek, Jiří | |
dc.contributor.author | Hošek, Petr | |
dc.contributor.author | Hrabcova, Karolina | |
dc.contributor.author | Bratova, Monika | |
dc.contributor.author | Kultan, Juraj | |
dc.contributor.author | Hrnčiarik, Michal | |
dc.contributor.author | Černovská, Markéta | |
dc.contributor.author | Zemanová, Petra | |
dc.contributor.author | Krejčí, Jana | |
dc.contributor.author | Koubková, Leona | |
dc.contributor.author | Stastny, Marek | |
dc.contributor.author | Svatoň, Martin | |
dc.date.accessioned | 2023-12-12T08:40:36Z | |
dc.date.available | 2023-12-12T08:40:36Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2107 | |
dc.description.abstract | BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on serious adverse events (i.e., those of grade >=3), we evaluated overall survival (OS), progression-free survival (PFS), as well as objective response rate (ORR) to treatment. PATIENTS AND METHODS: We retrospectively analyzed a set of patients from the TULUNG database of NSCLC treated with nivolumab in eight oncology centers. We evaluated OS data based upon this set. To reduce possible bias, we further evaluated a subgroup of patients treated at the University Hospital in Pilsen, where the occurrence of adverse events, PFS, and ORR were independently examined by two experienced physicians. Survival statistics were evaluated using the Kaplan-Meier method and Cox analysis. RESULTS: We observed significantly greater OS, PFS, and ORR in the group of patients experiencing adverse events upon nivolumab treatment versus in those patients without such events. Although the univariable model analyzing the data set of all patients demonstrated higher OS in patients with serious adverse events, only a nonsignificant trend was observed in the Cox multivariable model. In a subgroup of patients with PFS and ORR evaluation, we did observe significant, favorable effects for patients having had serious adverse effects. CONCLUSION: Patients experiencing severe adverse events show a tendency toward better OS, PFS, and ORR compared to patients without or having only mild adverse events with nivolumab treatment. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.21873/invivo.13324 | |
dc.rights | Creative Commons Uveďte původ-Neužívejte dílo komerčně-Nezpracovávejte 4.0 International | cs |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivativeWorks 4.0 International | en |
dc.title | Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode | |
dc.date.updated | 2024-03-12T07:40:36Z | |
dc.subject.keyword | Lung cancer | en |
dc.subject.keyword | adverse events | en |
dc.subject.keyword | nivolumab | en |
dc.subject.keyword | overall survival | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/UNCE/MED/UNCE/MED/006 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5102 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNM | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNP-19 | |
dc.date.embargoStartDate | 2024-03-12 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.21873/invivo.13324 | |
dc.identifier.utWos | 001108917300024 | |
dc.identifier.eidScopus | 2-s2.0-85169391501 | |
dc.identifier.obd | 634784 | |
dc.identifier.pubmed | 37652490 | |
dc.subject.rivPrimary | 30000::30200::30203 | |
dc.subject.rivSecondary | 30000::30200::30204 | |
dcterms.isPartOf.name | In Vivo | |
dcterms.isPartOf.issn | 0258-851X | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 37 | |
dcterms.isPartOf.journalIssue | 5 | |
uk.faculty.primaryId | 111 | |
uk.faculty.primaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.primaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryId | 108 | |
uk.faculty.secondaryId | 54 | |
uk.faculty.secondaryId | 110 | |
uk.faculty.secondaryId | 112 | |
uk.faculty.secondaryId | 52 | |
uk.faculty.secondaryName | 1. lékařská fakulta | cs |
uk.faculty.secondaryName | First Faculty of Medicine | en |
uk.faculty.secondaryName | Fakultní nemocnice Plzeň | cs |
uk.faculty.secondaryName | University Hospital in Pilsen | en |
uk.faculty.secondaryName | 3. lékařská fakulta | cs |
uk.faculty.secondaryName | Third Faculty of Medicine | en |
uk.faculty.secondaryName | Lékařská fakulta v Hradci Králové | cs |
uk.faculty.secondaryName | Faculty of Medicine in Hradec Kralove | en |
uk.faculty.secondaryName | Fakultní nemocnice v Motole | cs |
uk.faculty.secondaryName | Motol University Hospital | en |
uk.department.primaryId | 1407 | |
uk.department.primaryName | Klinika pneumologie a ftizeologie | cs |
uk.department.primaryName | Department of Pneumology and Phtisiology | en |
uk.department.secondaryId | 100012968318 | |
uk.department.secondaryId | 1529 | |
uk.department.secondaryId | 636 | |
uk.department.secondaryId | 700 | |
uk.department.secondaryId | 100010693561 | |
uk.department.secondaryId | 5000002710 | |
uk.department.secondaryName | Biomedicínské centrum | cs |
uk.department.secondaryName | Biomedical Center | en |
uk.department.secondaryName | Onkologická klinika 1. LF UK a VFN | cs |
uk.department.secondaryName | Department of Oncology | en |
uk.department.secondaryName | Klinika pneumologie 3. LF UK a FNB | cs |
uk.department.secondaryName | Department of Pneumology 3FM CU and UHB | en |
uk.department.secondaryName | Klinika onkologie a radioterapie | cs |
uk.department.secondaryName | Department of Oncology and Radiotherapy | en |
uk.department.secondaryName | Pneumologická klinika 2. LF UK a FN Motol | cs |
uk.department.secondaryName | Department of Pneumology, 2nd Faculty of Medicine and Motol University Hospital | en |
uk.department.secondaryName | Klinika pneumologie a ftizeologie | cs |
uk.department.secondaryName | Department of Pneumology and Phtisiology | en |
dc.description.pageRange | 2229-2236 | |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer | en |